ReviewsTranscatheter therapies for tricuspid valve regurgitationZaccone, Gregorio; Di Pasquale, Mattia; Fiorina, Claudia; Curello, Salvatore; Metra, Marco; Adamo, MariannaAuthor Information Cardiac Catheterization Laboratory and Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy Correspondence to Marco Metra, MD, Cardiology Unit, ASST Spedali Civili di Brescia, Piazzale Spedali Civili, 1, 25123 Brescia, Italy Tel: +39 3356460581; e-mail: [email protected] Received 27 April, 2020 Revised 29 May, 2020 Accepted 18 June, 2020 Journal of Cardiovascular Medicine: December 2020 - Volume 21 - Issue 12 - p 964-974 doi: 10.2459/JCM.0000000000001062 Buy Metrics Abstract Tricuspid regurgitation, either isolated or associated with left-valve disease, has a strong impact on outcome. Surgical treatment of tricuspid regurgitation has increased in recent years, but in-hospital mortality remains high probably due to the risk profile of the recipients. As a consequence, most of the patients with severe tricuspid regurgitation, especially if isolated, remain untreated. Transcatheter tricuspid valve interventions are rapidly spreading as alternative options to open-heart procedures fulfilling this important unmet need. Although patient selection and timing of intervention are unclear, many devices have been developed in recent years for both repair and replacement of tricuspid valve. Repair tools can be targeted to leaflets or annulus. Replacement devices include heterotopic and orthotropic systems. The aim of this review is to report possible indications and summarize current data about the different devices available for transcatheter tricuspid valve interventions. © 2020 Italian Federation of Cardiology - I.F.C. All rights reserved.