Review articlesCoronavirus disease 2019 and cardiovascular implicationsFrattini, Silviaa; Maccagni, Gloriab; Italia, Leonardob; Metra, Marcob; Danzi, Gian B.aAuthor Information aDivision of Cardiology, Ospedale di Cremona, Cremona bCardiology, ASST Spedali Civili; Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Cardiothoracic Department, Civil Hospitals, Brescia, Italy Correspondence to Gian B. Danzi, MD, Division of Cardiology, Ospedale di Cremona, Viale Concordia 1, 26100 Cremona, Italy Tel: +39 0372 405333; e-mail: email@example.com Received 7 April, 2020 Revised 11 June, 2020 Accepted 14 June, 2020 Journal of Cardiovascular Medicine: October 2020 - Volume 21 - Issue 10 - p 725-732 doi: 10.2459/JCM.0000000000001068 Buy Metrics Abstract The coronavirus disease 2019 (COVID-19) has important implications for the cardiovascular care of patients. COVID-19 interacts with the cardiovascular system on multiple levels, increasing morbidity in patients with underlying cardiovascular conditions and favoring acute myocardial injury and dysfunction. COVID-19 infection may also have long-term implications for overall cardiovascular health. Many issues regarding the involvement of the cardiovascular system remain controversial. Despite angiotensin-converting enzyme 2 serving as the site of entry of the virus into the cells, the role of angiotensin-converting enzyme inhibitors or AT1 blockers requires further investigation. Therapies under investigation for COVID-19 may have cardiovascular side effects. Treatment of COVID-19, especially the use of antivirals, must be closely monitored. This article is a review of the most updated literature. © 2020 Italian Federation of Cardiology - I.F.C. All rights reserved.