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Right heart dysfunction

from pathophysiologic insights to therapeutic options

a translational overview

Mercurio, Valentinaa,*; Palazzuoli, Albertob,*; Correale, Michelec; Lombardi, Carlod; Passantino, Andreae; Ravera, Aliced; Ruocco, Gaetanob; Sciatti, Edoardod; Triggiani, Marcod; Lagioia, Roccoe; Scrutinio, Domenicoe; Tocchetti, Carlo G.a; Nodari, Savinad

Journal of Cardiovascular Medicine: November 2018 - Volume 19 - Issue 11 - p 613–623
doi: 10.2459/JCM.0000000000000700

The right ventricle has become increasingly studied in cardiovascular research. In this article, we describe specific pathophysiological characteristics of the right ventricle, with special focus on functional and molecular modifications as well as therapeutic strategies in right ventricular dysfunction, underlining the differences with the left ventricle. Then we analyze the main imaging modalities to assess right ventricular function in different clinical settings. Finally, we acknowledge main therapeutic advances for treatment of right heart diseases.

aDepartment of Translational Medical Sciences, Federico II University, Naples

bDepartment of Internal Medicine, Cardiovascular Diseases Unit, University of Siena, Siena

cCardiology Department, University of Foggia, Foggia

dCardiology Section, Department of Clinical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia

eIstituti Clinici Scientifici Maugeri. Istituto di Cassano delle Murge. I.R.C.C.S., Cassano Murge, Bari, Italy

Correspondence to Professor Carlo G. Tocchetti, MD, PhD, FHFA, Dipartimento di Scienze Mediche Traslazionali, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy Tel: +39 081 746 3714; fax: +39 081 746 2246; e-mail:

Received 28 March, 2018

Revised 6 July, 2018

Accepted 11 July, 2018

© 2018 Italian Federation of Cardiology. All rights reserved.