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Health-related quality of life of hypertension in China

a systematic review and meta-analysis

Ye, Runyu*; Liu, Kai*; Zhang, Zhipeng; Gong, Shenzhen; Chen, Xiaoping

Journal of Cardiovascular Medicine: August 2018 - Volume 19 - Issue 8 - p 430–438
doi: 10.2459/JCM.0000000000000678
Research articles: Prevention

Aims Many observational studies have shown a lower health-related quality of life (HRQOL) of hypertension patients. This study aimed to summarize the association between hypertension and HRQOL in the Chinese population.

Methods We systematically searched the observational studies in the following databases: Medline, PubMed, Embase, Science Citation Index, Chinese National Knowledge Infrastructure, VIP and WanFang Data from 1 January 1990 to 1 October 2017.

Results A total of 33 studies were included in this systematic review. Twenty-one of them presented worse quality of life in hypertensive individuals. The meta-analysis showed lower scores in hypertensive individuals for the eight domains and physical components (−4.93; 95% confidence interval −8.40 to −1.47), and no statistical difference in mental components (−1.62; 95% confidence interval −4.26 to 1.02).

Conclusion Among Chinese patients, HRQOL of hypertensive patients is worse than that of normotensive individuals. These data suggest that maintenance of normotension offers benefits on patient-centered outcomes, in addition to other well established cardiovascular benefits.

Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

Correspondence to Xiaoping Chen, Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China Tel: +86 028 85422343; fax: +86 028 85422175; e-mail:

Received 4 March, 2018

Revised 14 April, 2018

Accepted 8 May, 2018

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