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Chemotherapy-induced cardiotoxicity

new insights into mechanisms, monitoring, and prevention

Cadeddu Dessalvi, Christiana,*; Deidda, Martinoa,*; Mele, Donatob,*; Bassareo, Pier P.a; Esposito, Robertac; Santoro, Ciroc; Lembo, Mariac; Galderisi, Maurizioc,†; Mercuro, Giuseppea,†

Journal of Cardiovascular Medicine: July 2018 - Volume 19 - Issue 7 - p 315–323
doi: 10.2459/JCM.0000000000000667
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Chemotherapy-induced cardiotoxicity (CTX) remains a determining factor for the quality of life and mortality of patients treated with potentially cardiotoxic drugs. Considerable advances have been made in this field with increase in awareness regarding chemotherapy-induced CTX, which has changed the treatment approach to include cardiovascular risk among the first factors to be evaluated before therapy. Moreover, a better understanding of the pathophysiology of chemotherapy-induced CTX has also facilitated early identification of patients at risk with the help of new imaging technologies. The newly developed imaging tools in cardio-oncology have led to the introduction of novel parameters for evaluation of myocardial function. This, together with a renewed standardization of measurements, has increased the adherence to monitoring protocols. With respect to treatment and prevention, researchers have started focusing attention on the development of new strategies as well as new cardioprotective agents that will play a crucial role in the prevention of CTX in the near future.

aDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari

bCardiology Unit, University Hospital of Ferrara, Ferrara

cDepartment of Advanced Biomedical Sciences, Federico II University Hospital, Naples, Italy

Correspondence to Christian Cadeddu Dessalvi, MD, PhD, FESC, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy Tel: +39 0706754951 4230; fax: +39 0706754951 4230; e-mail: cadedduc@unica.it

Received 7 February, 2018

Revised 6 April, 2018

Accepted 10 April, 2018

© 2018 Italian Federation of Cardiology. All rights reserved.