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Incremental value of right atrial strain for early diagnosis of hemodynamic deterioration in pulmonary hypertension: a new noninvasive tool for a more comprehensive diagnostic paradigma

Piccinino, Cristinaa; Giubertoni, Ailiaa; Zanaboni, Jacopoa; Gravellone, Miriama; Sola, Danieleb; Rosso, Robertaa; Ferrarotti, Lorenaa; Marino, Paolo Nicolaa

Journal of Cardiovascular Medicine: November 2017 - Volume 18 - Issue 11 - p 866–874
doi: 10.2459/JCM.0000000000000525
Research articles: Acute heart failure

Aims Increased right atrial size is related to adverse prognosis in pulmonary hypertension. The potential incremental value of right atrial function assessment is still unclear. We tested the relationship between right atrial two-dimensional speckle-tracking echocardiography impairment and hemodynamic, functional and clinical deterioration in patients with pulmonary hypertension.

Methods We prospectively evaluated 36 patients (27 female, 9 male; mean age 68 ± 13 years) with suspected pulmonary hypertension undergoing right heart catheterization and 16 matched controls. All patients underwent baseline evaluation by New York Heart Association functional class, 6-min walking test, brain natriuretic peptide (BNP), and standard two-dimensional echocardiography in less than 48 h of right heart catheterization. Right atrial two-dimensional speckle-tracking echocardiography was assessed by averaging all segments in standard four-chamber apical view.

Results Right atrial global integral strain was significantly lower in patients compared with controls (11.40 ± 5.22% vs. 25.72 ± 5.95 P < 0.001). Moreover, right atrial global strain, but not right atrial area or volume, was correlated with invasively measured cardiac index (CI) (r = 0.72; P < 0.0001) and pulmonary vascular resistances in all patients, even though stronger in subjects with precapillary pulmonary hypertension (r = −0.42, P = 0.018; r = −0.54, P = 0.007 respectively; P = 0.007). It was also correlated with New York Heart Association (P = 0.027), BNP (P = 0.002), and 6-min walking test (P = 0.006). After multivariate analysis including right atrial volume, tricuspid annular plane systolic excursion, left atrial strain, and BNP, right atrial global strain showed the strongest correlation with CI. Area under the curve optimal cutoff for predicting CI at least 2.4 l/min/m2 was 17% (area under the curve: 0.83, sensitivity: 90%, specificity: 54%).

Conclusion Right atrial global strain can identify right atrial functional impairment before structural changes and may be implemented in a comprehensive, noninvasive right heart assessment for diagnosis and follow-up of pulmonary hypertension patients.

aDepartment of Cardiology

bDivision of Internal Medicine, Hospital Maggiore della Carità, University of Piemonte Orientale, Novara, Italy

Correspondence to Cristina Piccinino, MD, Hospital maggiore della carità, Novara, Italy E-mail:

Received 24 November, 2016

Revised 8 March, 2017

Accepted 15 March, 2017

© 2017 Italian Federation of Cardiology. All rights reserved.