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Contrast-induced kidney injury: how does it affect long-term cardiac mortality?

Andreis, Alessandroa; Budano, Carloa; Levis, Mariob; Garrone, Paoloa; Usmiani, Tullioa; D’Ascenzo, Fabrizioa; De Filippo, Ovidioa; D’Amico, Maurizioa; Bergamasco, Laurac; Biancone, Luigid; Marra, Sebastianoa; Colombo, Antonioe; Gaita, Fiorenzoa

Journal of Cardiovascular Medicine: November 2017 - Volume 18 - Issue 11 - p 908–915
doi: 10.2459/JCM.0000000000000543
Research articles: Interventional cardiology

Aims Contrast-induced acute kidney injury (CIAKI) is a common complication after coronary angiography or percutaneous revascularization (PCI). This study aimed to investigate the association of CIAKI with long-term cardiovascular adverse events.

Methods In total, 980 patients undergoing coronary angiography/PCI were assessed in this prospective cohort study. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCE) and cardiac death (CVD) during an 8-year follow-up. Glomerular filtration rate change during the follow-up was the secondary endpoint.

CIAKI was defined as a serum creatinine increase at least 0.3 mg/dl in 48 h or at least 50% in 7 days.

Results CIAKI was observed in 69 patients (7%). Chronic kidney disease [relative risk (RR) = 4, P < 0.01], reduced ejection fraction (RR = 2.88, P < 0.01), CIAKI risk score at least 4 (RR = 2.64, P = 0.02), and emergency coronary angiography/PCI (RR = 3.87, P < 0.01) increased CIAKI risk, whereas statins were protective (RR = 0.32, P < 0.01).

Patients with CIAKI had higher rates of 8-year cardiovascular adverse events: 54 versus 15% MACCE (RR = 6.67, P < 0.01), 38 versus 4% CVD (RR = 15.73, P < 0.01). Among other factors, CIAKI was the strongest predictor of 8-year MACCE (RR = 3.16, P < 0.01) and CVD (RR = 7.34, P < 0.01).

During the follow-up, glomerular filtration rate declined drastically in CIAKI patients: 70 versus 39% had chronic kidney disease stage worsening (P < 0.01) and 8 versus 0.3% started hemodialysis (P < 0.01).

Conclusion We found a strong correlation between CIAKI and poor long-term cardiac outcomes. Apparently showing up as a transient, functional impairment of kidney function, CIAKI implies an organic damage with structural modifications leading to significant kidney deterioration over time, responsible for an increased risk of long-term cardiac events. Statins significantly reduced CIAKI occurrence. A careful management of high-risk patients is needed to limit long-term complications of coronary angiography/PCI.

aDivision of Cardiology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino

bDepartment of Oncology, Radiation Oncology

cDepartment of Surgical Sciences, University of Turin

dDepartment of Nephrology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin

eInterventional Cardiology Unit, San. Raffaele Scientific Institute, Milan, Italy

Correspondence to Alessandro Andreis, MD, Division of Cardiology, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Corso Bramante 88, 10126 Turin, Italy Tel: +390116335564; fax: +390116335564; e-mail:

Received 30 January, 2017

Revised 1 June, 2017

Accepted 10 June, 2017

© 2017 Italian Federation of Cardiology. All rights reserved.