Acute coronary syndromesBleeMACS rationale and design of the studyD’Ascenzo, Fabrizio; Abu-Assi, Emad; Raposeiras-Roubín, Sergio; Simao Henriques, José Paulo; Saucedo, Jorge; González-Juanatey, José Ramon; Wilton, Stephen B.; Kikkert, Wouter J.; Nuñez-Gil, Iván; Ariza-Sole, Albert; Song, Xiantao; Alexopoulos, Dimitrios; Liebetrau, Christoph; Kawaji, Tetsuma; Moretti, Claudio; Huczek, Zenon; Nie, Shao-Ping; Fujii, Toshiharu; Correia, Luis Claudio; Kawashiri, Masa-aki; García-Acuña, José María; Southern, Danielle; Alfonso, Emilio; Terol, Belén; Garay, Alberto; Zhang, Dongfeng; Chen, Yalei; Xanthopoulou, Ioanna; Osman, Neriman; Möllmann, Helge; Shiomi, Hiroki; Giordana, Francesca; Scarano, Silvia; Gaita, Fiorenzo; Kowara, Michal; Filipiak, Krzysztof J.; Wang, Xiao; Yan, Yan; Fan, Jing-Yao; Ikari, Yuji; Nakahayshi, Takuya; Sakata, Kenji; Yamagishi, Masakazu; Kalpak, Oliver; Kedev, SaskoAuthor Information aDipartimento di Scienze Mediche, Divisione di Cardiologia, Città della Salute e della Scienza, Turin, Italy bUniversity Clinical Hospital, Santiago de Compostela, Spain cUniversity Academic Medical Center, Amsterdam, The Netherlands dNorthShore University Hospital, Chicago, Illinois, USA eLibin Cardiovascular Institute of Alberta, Calgary, Canada fSan Carlos Hospital, Madrid gBellvitge Hospital, Barcelona, Spain hAnzhen Hospital, Beijing, China iUniversity Patras Hospital, Athens, Greece jKerckhoff Heart and Thorax Center, Frankfurt, Germany kUniversity Clinical Hospital, Kyoto, Japan lUniversity Clinical Hospital, Warsaw, Poland mInstitute of Heart, Lung and Blood Vessel Disease, Beijing, China nTokai University School of Medicine, Tokyo, Japan oUniversity Bahian Medical School, Salvador, Brazil pDivision of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan qUniversity Clinic of Cardiology, Skopje, Macedonia Correspondence to Fabrizio D’Ascenzo, Cardiologist, Division of Cardiology University of Turin, Città della Salute e Della Scienza, corso Bramante 88/90 10126 Torino, Italy E-mail: [email protected] Received 21 October, 2015 Revised 11 December, 2015 Accepted 29 December, 2015 Journal of Cardiovascular Medicine: October 2016 - Volume 17 - Issue 10 - p 744-749 doi: 10.2459/JCM.0000000000000362 Buy Metrics Abstract Background Bleeding events after an acute coronary syndrome have a negative impact on prognosis. Available risk scores are limited by suboptimal accuracy, prediction of only in-hospital events and absence of patients treated with new antiplatelet agents in the current era of widespread use of percutaneous coronary intervention. Design The BleeMACS (Bleeding complications in a Multicenter registry of patients discharged after an Acute Coronary Syndrome) project is a multicenter investigator-initiated international retrospective registry that enrolled more than 15 000 patients discharged with a definitive diagnosis of acute coronary syndrome and treated with percutaneous revascularization. The primary end point is the incidence of major bleeding events requiring hospitalization and/or red cell transfusion concentrates within 1 year. An integer risk score for bleeding within the first year after hospital discharge will be developed from a multivariate competing-risks regression. Conclusion The BleeMACS registry collaborative will allow development and validation of a risk score for prediction of major bleeding during follow-up for patients receiving contemporary therapies for acute coronary syndrome. © 2016 Italian Federation of Cardiology. All rights reserved.