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Risk prediction of contrast-induced nephropathy by ACEF score in patients undergoing coronary catheterization

Capodanno, Davide; Ministeri, Margherita; Dipasqua, Fabio; Dalessandro, Veronica; Cumbo, Silvia; Gargiulo, Giuseppe; Tamburino, Corrado

Journal of Cardiovascular Medicine: July 2016 - Volume 17 - Issue 7 - p 524–529
doi: 10.2459/JCM.0000000000000215
Contrast induced nephropathy

Aims To explore the ability of the ACEF score to predict the incidence of contrast-induced nephropathy (CIN) in patients undergoing coronary angiography with or without percutaneous coronary intervention.

Methods A total of 706 patients undergoing coronary angiography ± percutaneous coronary intervention (PCI) between March 2011 and October 2011 were analyzed. CIN using different definitions was termed as CINnarrow (rise in serum creatinine ≥0.5 mg/dl) and CINbroad (rise in serum creatinine ≥0.5 mg/dl and/or ≥25% increase in baseline serum creatinine).

Results The mean ACEF score was 1.5 ± 0.6. Overall incidences of CINnarrow and CINbroad were 5.5% and 13.6%, respectively. There was a significant gradient in the incidence of CINnarrow (2.9%, 3.9%, 10.6% in the I, II, and III tertiles, respectively, P < 0.001) and CINbroad (9.1%, 14.2%, 17.9% in the I, II, and III tertiles, respectively, P = 0.021) across increasing ACEF tertiles. The ACEF score was independently associated with the risk of CINnarrow (adjusted odds ratio [OR] 1.6, 95% confidence interval [CI] 1.0–2.7; P = 0.047). Discrimination was more satisfactory when using the ACEF as a predictor of CINnarrow (c-statistic 0.71, 95% 0.63–0.79).

Conclusion The ACEF score is an independent and potentially useful predictor of CIN defined as rise in serum creatinine ≥0.5 mg/dl.

aFerrarotto Hospital, University of Catania

bETNA Foundation, Catania, Italy

Correspondence to Davide Capodanno, MD, PhD, Cardiology Department, Ferrarotto Hospital, University of Catania, Via Citelli 6, 95124 Catania, Italy Tel: +39 0957436202; fax: +39 095362429; e-mail:

Received 24 June, 2013

Revised 10 August, 2014

Accepted 11 August, 2014

© 2016 Italian Federation of Cardiology. All rights reserved.