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Heart failure in patients with human immunodeficiency virus: a review of the literature

Cannillo, Margherita; D’Ascenzo, Fabrizio; Grosso Marra, Walter; Cerrato, Enrico; Calcagno, Andrea; Omedè, Pierluigi; Bonora, Stefano; Mancone, Massimo; Vizza, Dario; DiNicolantonio, James J.; Pianelli, Martina; Barbero, Umberto; Gili, Sebastiano; Annone, Umberto; Raviola, Alessio; Salera, Davide; Mistretta, Elisa; Vilardi, Ilaria; Colaci, Chiara; Abbate, Antonio; Zoccai, Giuseppe Biondi; Moretti, Claudio; Gaita, Fiorenzo

Journal of Cardiovascular Medicine: May 2015 - Volume 16 - Issue 5 - p 383–389
doi: 10.2459/JCM.0000000000000168
Reviews: Comorbidities

Coronary artery disease represents the leading cause of death for HIV patients treated with highly active antiretroviral treatment. Besides this, an extensive amount of data related to the risk of overt heart failure and consequently of atrial fibrillation and sudden cardiac death (SCD) in this population has been reported. It seems that persistent deregulation of immunity in HIV-infected patients is a common pathway related to both of these adverse clinical outcomes. Despite the fact that atrial fibrillation and heart failure are relatively common in HIV, few data are reported about screening, diagnosis, and potential treatment of these conditions.

aCittà Della Salute e Della Scienza, Division of Cardiology, University of Turin, Italy

bUnit of Infectious Diseases, University of Turin, Department of Medical Sciences, Amedeo di Savoia Hospital, Turin, Italy

cDepartment of Cardiovascular and Pulmonary Sciences, Policlinico Umberto I ‘Sapienza’, University of Rome, Italy

dWegmans Pharmacy, Ithaca, NY, USA

eVCU Pauley Heart Center, Richmond, VA, USA

Correspondence to Dr Fabrizio D’Ascenzo, Division of Cardiology, University of Turin, S. Giovanni Battista ‘Molinette’ Hospital, Corso Bramante 88-90, 10126 Turin, Italy. E-mail:

Received 28 August, 2013

Revised 24 March, 2014

Accepted 24 March, 2014

© 2015 Italian Federation of Cardiology. All rights reserved.