Exercise and cardiovascular prevention: Narrative reviewsWhy is functional capacity decreased in hypertensive patients? From mechanisms to clinical studiesTadic, Marijana; Ivanovic, BranislavaAuthor Information aUniversity Clinical Hospital Center ‘Dr Dragisa Misovic’ bClinical Centre of Serbia, Clinic for Cardiology cMedical School of Belgrade, University of Belgrade, Belgrade, Serbia Correspondence to Marijana Tadic, MD, PhD, University Clinical Hospital Center ‘Dr Dragisa Misovic’, Heroja Milana Tepica 1, 11000 Belgrade, Serbia E-mail: [email protected] Received 28 June, 2013 Revised 7 August, 2013 Accepted 6 September, 2013 Journal of Cardiovascular Medicine: June 2014 - Volume 15 - Issue 6 - p 447-455 doi: 10.2459/JCM.0000000000000050 Buy Metrics Abstract The influence of arterial hypertension on functional capacity is poorly understood. Studies have shown that peak oxygen consumption has been reduced in hypertensive patients, but the mechanisms are unclear. Left ventricular systolic and diastolic dysfunction, as well as left ventricular hypertrophy, are associated with lower functional capacity in patients with arterial hypertension. Furthermore, some investigations found a significant relationship between right ventricular systolic function and functional capacity in the general population. The aim of this review was to summarize current knowledge about the mechanisms of reduced functional capacity in hypertensive patients, including the impact of systemic and pulmonary circulations, as well as the influence of the left and right ventricle on oxygen consumption. Additionally, we reviewed all clinical studies regarding functional capacity in the population with arterial hypertension. © 2014 Italian Federation of Cardiology. All rights reserved.