A variable proportion, up to 30%, of patients who undergo cardiac resynchronization therapy (CRT) do not benefit from treatment. The aim of the Cardiac Resynchronization Therapy MOdular REgistry (CRT MORE) is to determine whether specific electrocardiographic and radiographic parameters can be used to predict clinical and echocardiographic response to CRT.
The CRT MORE is a prospective, single-arm, multicenter cohort study designed to evaluate the electrocardiographic and radiographic predictors of response to CRT. All study patients receive a pacemaker or implantable defibrillator for CRT delivery in accordance with current guidelines. Enrolment started in December 2011 and is scheduled to end in November 2013. Approximately 1100 consecutive patients will be enrolled in 30 Italian centers and will be followed up for 60 months after implantation. The primary endpoint is the improvement in clinical (Clinical Composite Score) and echocardiographic (a decrease of ≥15% in left ventricular end-systolic volume) parameters at the 6-month follow-up visit.
This study might provide important information about which electrocardiographic and radiographic parameters better predict CRT response.
aClinica Mediterranea, Napoli
bUniversità di Padova, Padova
cOspedale S’Anna, San Fermo della Battaglia (CO)
dOspedale SS Trinità, Cagliari
eOspedale Gavazzeni, Bergamo
fOspedale Carlo Poma, Mantova
gOspedale Sant’Antonio Abate, Gallarate (VA)
hClinica San Michele, Maddaloni (CE)
iOspedale Monaldi, Napoli
jOspedale Poliambulanza, Brescia
kOspedale Panico, Tricase (LE)
lOspedale Pugliese-Ciaccio, Catanzaro
mOspedale SS Giacomo e Cristoforo, Massa
nBoston Scientific Italia, Milan
oOspedale Careggi, Università di Firenze, Firenze, Italy
Correspondence to Giuseppe Stabile, MD, Laboratorio di Elettrofisiologia, Clinica Mediterranea, Via Orazio 2, 80100 Napoli, Italy Tel: +39 0817259641; fax: +39 0817259777; e-mail: email@example.com
Received 24 February, 2013
Revised 26 April, 2013
Accepted 15 June, 2013