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Cardiac Resynchronization Therapy MOdular REgistry: ECG and Rx predictors of response to cardiac resynchronization therapy (NCT01573091)

Stabile, Giuseppe; Bertaglia, Emanuele; Botto, Gianluca; Isola, Francesco; Mascioli, Giosuè; Pepi, Patrizia; Caico, Salvatore I.; De Simone, Antonio; D’Onofrio, Antonio; Pecora, Domenico; Palmisano, Pietro; Maglia, Giampiero; Arena, Giuseppe; Malacrida, Maurizio; Padeletti, Luigi

Journal of Cardiovascular Medicine: December 2013 - Volume 14 - Issue 12 - p 886–893
doi: 10.2459/JCM.0b013e3283644bb2
Original articles: Heart failure
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Aims A variable proportion, up to 30%, of patients who undergo cardiac resynchronization therapy (CRT) do not benefit from treatment. The aim of the Cardiac Resynchronization Therapy MOdular REgistry (CRT MORE) is to determine whether specific electrocardiographic and radiographic parameters can be used to predict clinical and echocardiographic response to CRT.

Methods The CRT MORE is a prospective, single-arm, multicenter cohort study designed to evaluate the electrocardiographic and radiographic predictors of response to CRT. All study patients receive a pacemaker or implantable defibrillator for CRT delivery in accordance with current guidelines. Enrolment started in December 2011 and is scheduled to end in November 2013. Approximately 1100 consecutive patients will be enrolled in 30 Italian centers and will be followed up for 60 months after implantation. The primary endpoint is the improvement in clinical (Clinical Composite Score) and echocardiographic (a decrease of ≥15% in left ventricular end-systolic volume) parameters at the 6-month follow-up visit.

Conclusion This study might provide important information about which electrocardiographic and radiographic parameters better predict CRT response.

aClinica Mediterranea, Napoli

bUniversità di Padova, Padova

cOspedale S’Anna, San Fermo della Battaglia (CO)

dOspedale SS Trinità, Cagliari

eOspedale Gavazzeni, Bergamo

fOspedale Carlo Poma, Mantova

gOspedale Sant’Antonio Abate, Gallarate (VA)

hClinica San Michele, Maddaloni (CE)

iOspedale Monaldi, Napoli

jOspedale Poliambulanza, Brescia

kOspedale Panico, Tricase (LE)

lOspedale Pugliese-Ciaccio, Catanzaro

mOspedale SS Giacomo e Cristoforo, Massa

nBoston Scientific Italia, Milan

oOspedale Careggi, Università di Firenze, Firenze, Italy

Correspondence to Giuseppe Stabile, MD, Laboratorio di Elettrofisiologia, Clinica Mediterranea, Via Orazio 2, 80100 Napoli, Italy Tel: +39 0817259641; fax: +39 0817259777; e-mail: gmrstabile@tin.it

Received 24 February, 2013

Revised 26 April, 2013

Accepted 15 June, 2013

© 2013 Italian Federation of Cardiology. All rights reserved.