Genesis of remote conditioning: action at a distance – ‘hypotheses non fingo’?Przyklenk, Karin; Whittaker, PeterJournal of Cardiovascular Medicine: March 2013 - Volume 14 - Issue 3 - p 180–186 doi: 10.2459/JCM.0b013e328358c8eb Guest Editor: Gerd Heusch Buy Abstract Author InformationAuthors Article MetricsMetrics Remote ischemic preconditioning is the phenomenon whereby brief episodes of ischemia–reperfusion applied in a distant organ or tissue render the myocardium resistant to infarction. The discovery of remote conditioning was not a serendipitous finding, but, rather, was predicted by mathematical modeling. In the current review, we describe how the hypothesis for remote conditioning was formulated and tested, how the paradigm has expanded to encompass a spectrum of remote triggers, and summarize the progress that has been made in elucidating the mechanisms responsible for this intriguing form of cardioprotection. aCardiovascular Research Institute bDepartment of Physiology cDepartment of Emergency Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA Correspondence to Karin Przyklenk, PhD, Cardiovascular Research Institute, Wayne State University School of Medicine, Elliman Building, Room 1107, 421 E Canfield, Detroit, MI 48201, USATel: +1 313 577 9047; fax: +1 313 577 8615; e-mail: firstname.lastname@example.org Received 12 July, 2012 Revised 20 July, 2012 Accepted 1 August, 2012 © 2013 Italian Federation of Cardiology. All rights reserved.