Images in cardiovascular medicinePercutaneous valve replacement in a young adult for radiation-induced aortic stenosisLatib, Azeem; Montorfano, Matteo; Figini, Filippo; Maisano, Francesco; Chieffo, Alaide; Benussi, Stefano; Bellanca, Raimondo; Gerli, Chiara; Spagnolo, Pietro; Alfieri, Ottavio; Colombo, AntonioAuthor Information aInterventional Cardiology Unit, San Raffaele Scientific Institute bInterventional Cardiology Unit, EMO-GVM Centro Cuore Columbus cDepartment of Cardiac Surgery, San Raffaele Scientific Institute dDepartment of Cardiac Anesthesia, San Raffaele Scientific Institute eCentre for Cardiovascular Prevention, San Raffaele Scientific Institute, Milan, Italy Correspondence to Azeem Latib, EMO-GVM Centro Cuore Columbus, 48 Via M. Buonarroti, 20145 Milan, ItalyTel: +39 024 812 920; fax: +39 024 819 3433; e-mail: [email protected] Received 17 October, 2011 Revised 1 January, 2012 Accepted 16 January, 2012 Journal of Cardiovascular Medicine: June 2012 - Volume 13 - Issue 6 - p 397-398 doi: 10.2459/JCM.0b013e3283517c4a Buy Metrics Abstract A 46-year-old woman known with relapsing Hodgkin's lymphoma diagnosed at age 5, treated with repeated cycles of radiotherapy and chemotherapy, presented with severe symptomatic radiation-induced aortic stenosis. She also had other late sequelae of radiotherapy including thyroid cancer, mediastinal fribrosis and left pulmonary fibrosis with severe restrictive lung disease and a newly diagnosed renal carcinoma. Due to the prohibitively high surgical risk and need for urgent treatment, she underwent successful transcatheter aortic valve replacement with transfemoral implantation of a 23 mm Edwards SAPIEN-XT prosthesis, which was performed without valvuloplasty of the noncalcified fibrotic valve. The final result was excellent with reduction of the transaortic gradient and no residual aortic regurgitation. © 2012 Italian Federation of Cardiology. All rights reserved.