Review articlesWomen survive breast cancer but fall victim to heart failure: the shadows and lights of targeted therapyMaurea, Nicola; Coppola, Carmela; Ragone, Gianluca; Frasci, Giuseppe; Bonelli, Annamaria; Romano, Carmela; Iaffaioli, Rosario VincenzoAuthor Information aCardiology Division Institute, INT ‘Fondazione G. Pascale’, Italy bDepartment of Colorectal Oncology, Italy cDepartment of Senology, National Cancer Institute G. Pascale Foundation, Naples, Italy Received 25 August, 2009 Revised 25 November, 2009 Accepted 15 December, 2009 Correspondence to Nicola Maurea, MD, Cardiology Division Institute, National Cancer Institute G. Pascale Foundation, via M. Semmola, 80131 Naples, Italy Tel: +39 081 590 3349; fax: +39 081 590 3829; e-mail: [email protected] Journal of Cardiovascular Medicine: December 2010 - Volume 11 - Issue 12 - p 861-868 doi: 10.2459/JCM.0b013e328336b4c1 Buy Metrics Abstract In many cases, early-stage breast cancer is now curable, and metastatic disease can be chronic consequent to the advent of new therapeutic tools. Unfortunately, some treatments have been associated with adverse cardiovascular effects. Indeed, in many breast cancer survivors, the risk of cardiovascular disease is higher than the risk of cancer recurrence. The clinical challenge of preventing cardiovascular complications in patients undergoing antineoplastic treatment has two aims, more effective life-saving treatment of patients, and prevention of morbidity and cardiovascular mortality in the short term and long term. The aim of the present study is to review the rapidly evolving therapeutic strategies designed to treat early-stage breast cancer. The review highlights the need for more data on the impact of new biological drugs (targeted therapy) on the cardiovascular apparatus. Finally, given the complexity of targeted and other novel treatments, cancer patients are best managed through a multidisciplinary approach. © 2010 Italian Federation of Cardiology. All rights reserved.