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Echocardiographic abnormalities and their correlation with bronchiectasis score in primary antibody deficiencies

Zeinaloo, Ali Akbar; Aghamohammadi, Asghar; Shabanian, Reza; Salavati, Ali; Abdollahzade, Sina; Rezaei, Nima; Alizadeh, Hooman; Zanjani, Keyhan Sayadpour; Kiani, Abdolrazagh

Journal of Cardiovascular Medicine: April 2010 - Volume 11 - Issue 4 - p 244–249
doi: 10.2459/JCM.0b013e3283347df3
Original articles

Background Primary antibody deficiencies are characterized by defective antibody production and recurrent infections. Patients usually present with recurrent respiratory tract infections with consequent chronic pulmonary damage and bronchiectasis, which could potentially influence cardiac function. Our aim was to assess noninvasively the cardiac complications due to pulmonary disease in patients with primary antibody deficiency.

Methods A cross-sectional series of patients with primary antibody deficiency syndromes from our referral immunology center were recruited. Individuals undergoing high-resolution computed tomography (HRCT) and transthoracic echocardiography were reviewed.

Results Thirty primary immunodeficient patients aged 5–55 years of age (21 males and 9 females) were enrolled in this study. Half of the patients (50%) were found to have bronchiectasis in HRCT imaging. In echocardiographic examination, 20 patients (67%) had at least one abnormality; among which pulmonary hypertension was the most common (33%). Patients with bronchiectasis had higher pulmonary artery pressures and HRCT bronchiectasis score was strongly correlated with pulmonary artery pressure (regression R = 0.59, P value = 0.001).

Conclusion Echocardiographic evaluation of right ventricular function and noninvasive estimation of pulmonary artery pressure could have an important diagnostic role in the follow-up and therapeutic management of patients with primary immune deficiency.

aGrowth and Development Research Center, Iran

bDepartment of Pediatrics, Pediatrics Center of Excellence, Iran

cDepartment of Pediatric Cardiology, Iran

dDepartment of Pediatric Radiology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran

Received 28 June, 2009

Revised 4 October, 2009

Accepted 22 October, 2009

Correspondence to Asghar Aghamohammadi, MD, Children's Medical Center, 62 Qarib Street, Keshavarz Blvd., Tehran 14194, Iran Tel: +98 21 6694 9662; fax: +98 21 6692 3054; e-mail:

© 2010 Italian Federation of Cardiology. All rights reserved.