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Myocardial infarction in a young patient with a previous history of repeated thrombophlebitis: combination of factor V Leiden and prothrombin G20210A gene polymorphisms with coronary artery disease

Mugnolo, Antonio; Toniolo, Mauro; Cicoira, Mariantonietta; Vassanelli, Francesca; Vassanelli, Corrado

Journal of Cardiovascular Medicine: February 2010 - Volume 11 - Issue 2 - p 125–126
doi: 10.2459/JCM.0b013e32832f5d1b
Case reports

We report a case of myocardial infarction at a young age in a person with a medical history of repeated thrombophlebitis, who was heterozygous for the prothrombin G20210A mutation and homozygous for factor V Leiden mutation. A coronary angiography revealed the presence of a moderate atherosclerotic plaque (60%) in the left anterior descending coronary artery, which gave rise to suspicion of a relationship between prothrombotic gene mutations and atherosclerosis. Genetic screening for inherited thrombophilia, especially in the presence of a strong familiarity or previous venous thrombosis, and the evaluation of atherosclerotic risk factors, may be critical information for primary prevention of arterial thrombosis.

Division of Cardiology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy

* Antonio Mugnolo and Mauro Toniolo contributed equally to the writing of this article.

Received 18 March, 2009

Revised 9 June, 2009

Accepted 11 June, 2009

Correspondence to Mariantonietta Cicoira, MD, PhD, Divisione di Cardiologia, Ospedale Civile Maggiore, P.le Stefani 1, 37126 Verona, Italy Tel: +39 045 812 3706; fax: +39 045 802 7307; e-mail:

© 2010 Italian Federation of Cardiology. All rights reserved.