Case reportsAcute haemodynamic effects of intra-aortic balloon pump and cardiac resynchronization therapyBonanno, Carlo; Ometto, Renato; La Vecchia, Luigi; Fontanelli, AlessandroAuthor Information Cardiology, S. Bortolo Hospital; Viale Rodolfi, 36; 36100 Vicenza, Italy Received 11 April, 2007 Revised 26 September, 2007 Accepted 1 October, 2007 Correspondence to Dr Carlo Bonanno, S. Bortolo Hospital, Viale Rodolfi, 37, 36100 Vicenza, Italy Tel: +39 0444 753644; fax: +39 0444 753162; e-mail: [email protected] Journal of Cardiovascular Medicine: July 2008 - Volume 9 - Issue 7 - p 719-724 doi: 10.2459/JCM.0b013e3282f2ccef Buy Metrics Abstract We report two cases in which intra-aortic balloon pump (IABP) was used successfully as a bridge to cardiac resynchronization therapy (CRT) to treat patients with refractory systolic heart failure. The study was designed to assess the acute haemodynamic effects of IABP coupled with CRT using standard haemodynamic monitoring. In both cases, a marked elevation of V-wave in pulmonary capillary wedge pressure (PCWP) was shown, and a moderate-to-severe functional mitral regurgitation was observed. IABP and CRT resulted in a significant acute improvement in aortic pressure, PCWP, and V-wave amplitude compared with baseline measurements and IABP alone. These results provide a basis for studies examining the haemodynamic effects of IABP support associated with CRT in patients with heart failure refractory to medical therapy. © 2008 Italian Federation of Cardiology. All rights reserved.