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Acute haemodynamic effects of intra-aortic balloon pump and cardiac resynchronization therapy

Bonanno, Carlo; Ometto, Renato; La Vecchia, Luigi; Fontanelli, Alessandro

Journal of Cardiovascular Medicine: July 2008 - Volume 9 - Issue 7 - p 719–724
doi: 10.2459/JCM.0b013e3282f2ccef
Case reports

We report two cases in which intra-aortic balloon pump (IABP) was used successfully as a bridge to cardiac resynchronization therapy (CRT) to treat patients with refractory systolic heart failure. The study was designed to assess the acute haemodynamic effects of IABP coupled with CRT using standard haemodynamic monitoring. In both cases, a marked elevation of V-wave in pulmonary capillary wedge pressure (PCWP) was shown, and a moderate-to-severe functional mitral regurgitation was observed. IABP and CRT resulted in a significant acute improvement in aortic pressure, PCWP, and V-wave amplitude compared with baseline measurements and IABP alone. These results provide a basis for studies examining the haemodynamic effects of IABP support associated with CRT in patients with heart failure refractory to medical therapy.

Cardiology, S. Bortolo Hospital; Viale Rodolfi, 36; 36100 Vicenza, Italy

Received 11 April, 2007

Revised 26 September, 2007

Accepted 1 October, 2007

Correspondence to Dr Carlo Bonanno, S. Bortolo Hospital, Viale Rodolfi, 37, 36100 Vicenza, Italy Tel: +39 0444 753644; fax: +39 0444 753162; e-mail:

© 2008 Italian Federation of Cardiology. All rights reserved.