Case reportsRegression of warfarin-resistant left atrial appendage thrombus after ablation of atrial fibrillation and permanent pacingOneglia, Carlo; Gardini, Armando; Benedini, Giuseppe; Cappato, Riccardo; Rusconi, CesareAuthor Information aCardiology Unit, S. Orsola Hospital, Brescia, Italy bArrhythmia and Electrophysiology Centre, Policlinico San Donato, University of Milan, San Donato Milanese (MI), Italy Received 4 December, 2005 Accepted 2 February, 2006 Correspondence to Dr Carlo Oneglia, Via Acquafredda 41, 25064 Gussago (BS), Italy E-mail: firstname.lastname@example.org Journal of Cardiovascular Medicine: August 2006 - Volume 7 - Issue 8 - p 628-630 doi: 10.2459/01.JCM.0000237912.18753.95 Buy Metrics Abstract Atrial fibrillation is the most common rhythm disturbance and can also occur in absence of true cardiac disease. However, also in these cases, it can generate left atrial appendage thrombi with systemic embolic potential. A regular and well conducted anticoagulant therapy with dicoumarol derivatives, as indicated in these patients, is not always successful. We report the case of a patient with lone atrial fibrillation and a left atrial appendage thrombus resistant to anticoagulant therapy with warfarin, which disappeared after catheter ablation of atrial fibrillation by electrical disconnection of the pulmonary veins, restoration of sinus rhythm and dual-chamber pacemaker implantation. © 2006 Italian Federation of Cardiology. All rights reserved.