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Developmental Dysplasia of the Hip in Patients with Connective-Tissue Disorders

Kerrigan, Alicia, MD1; Ayeni, Olufemi R., MD, PhD, FRCSC2; Kishta, Waleed, MD, PhD, FRCSC1

doi: 10.2106/JBJS.RVW.18.00092
Review Articles

  • » There is a scarcity of literature on the management of hip dysplasia in patients with connective-tissue disorders, including Down syndrome, Marfan syndrome, Ehlers-Danlos syndrome, Larsen syndrome, and osteogenesis imperfecta.
  • » These genetic conditions result in abnormal connective-tissue and ligamentous laxity, and they present a unique, more complex approach for the patient with developmental dysplasia of the hip.
  • » These patients may present at all ages and functional levels on a spectrum of developmental dysplasia of the hip ranging from mild to severe.
  • » Individualized treatment involves consideration of age, disease severity, comorbidities, and functional status.
  • » Treating orthopaedic surgeons may be the first to identify an undiagnosed connective-tissue disorder, and prompt genetic referral is crucial.

1Division of Orthopaedic Surgery, Department of Surgery, Western University, London, Ontario, Canada

2Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada

E-mail address for A. Kerrigan:

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Investigation performed at the Division of Orthopaedic Surgery, Department of Surgery, Western University, London, Ontario, Canada

Disclosure: No funding was received for this work. On the Disclosure of Potential Conflicts of Interest forms, which are provided with the online version of the article, one or more of the authors checked “yes” to indicate that the author had a relevant financial relationship in the biomedical arena outside the submitted work (

Copyright © 2019 by The Journal of Bone and Joint Surgery, Incorporated
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