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Cannabinoids in the Management of Musculoskeletal Pain

A Critical Review of the Evidence

Madden, Kim, MSc1,a; van der Hoek, Niek, BSc2; Chona, Simrun3; George, Annie3; Dalchand, Tristiana4; Baldawi, Hassan, MBBCh, BAO1; Mammen, George, PhD5,6; Bhandari, Mohit, MD, PhD, FRCSC1

doi: 10.2106/JBJS.RVW.17.00153
Review Article-Critical Analysis

  • * The purposes of the present scoping review were to identify (1) the available studies regarding the efficacy of cannabinoids for the management of musculoskeletal pain and related conditions and (2) the knowledge gaps and opportunities in this area of research.
  • * There is little high-quality evidence for medical cannabis in the core orthopaedic areas of arthritis, postoperative pain, back pain, and trauma-related pain.
  • * The “best available” evidence suggests cannabis can be effective for managing arthritis pain, back pain, and trauma-related pain, although the quality of the evidence is poor.
  • * Evidence regarding the use of cannabinoids for the management of postoperative pain is mixed.
  • * Research on pain control in patients with arthritis, conditions related to the spine, and traumatic injuries represents major under-represented areas of study for the role of cannabinoids, and high-quality Level-I studies are needed.

1Departments of Health Research Methods (K.M. and M.B.) and Surgery (H.B. and M.B.), McMaster University, Hamilton, Ontario, Canada

2Department of Medicine, University of Groningen, Groningen, the Netherlands

3OrthoEvidence, Inc., Burlington, Ontario, Canada

4University of Toronto, Toronto, Ontario, Canada

5Institute for Mental Health Policy Research, Toronto, Ontario, Canada

6Beleave, Inc., Hamilton, Ontario, Canada

aE-mail address for K. Madden:

Copyright © 2018 by The Journal of Bone and Joint Surgery, Incorporated
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