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Molecular Markers in Bone and Soft-Tissue Tumors

Wustrack, Rosanna, MD1,a; Cooper, Kumarasen, MD2,b; Weber, Kristy, MD2,c

doi: 10.2106/JBJS.RVW.15.00092
Review Article

  • ➢ Many sarcomas such as osteosarcoma have complex molecular compositions and behaviors that make standardized treatment difficult for patients with these tumors.
  • ➢ Chromosomal translocations are noted in specific bone and soft-tissue sarcomas, and there are molecular tests (polymerase chain reaction [PCR] and fluorescence in situ hybridization [FISH]) used for accurate diagnosis.
  • ➢ The translocations noted in sarcomas may allow future therapeutic targeting.

1University of California, San Francisco, San Francisco, California

2Departments of Pathology (K.C.) and Orthopaedic Surgery (K.W.), University of Pennsylvania, Philadelphia, Pennsylvania

aE-mail address for R. Wustrack:

bE-mail address for K. Cooper:

cE-mail address for K. Weber:

Copyright © 2016 by The Journal of Bone and Joint Surgery, Incorporated
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