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Pigmented Villonodular Synovitis

A Comprehensive Review and Proposed Treatment Algorithm

Stephan, Stephen R., BS1,a; Shallop, Brandon, MD1,b; Lackman, Richard, MD2,c; Kim, Tae Won B., MD2,d; Mulcahey, Mary K., MD1,e

doi: 10.2106/JBJS.RVW.15.00086
Review Article

  • ➢ Evidence now exists suggesting a neoplastic origin for pigmented villonodular synovitis, including a thorough description of the translocations involved.
  • ➢ Arthroscopic excision for localized pigmented villonodular synovitis allows for both minimal recurrence and morbidity when compared with open excision; however, open excision still plays an important role in treating posterior compartment nodules.
  • ➢ The optimal surgical treatment for diffuse pigmented villonodular synovitis is still a matter for debate, with combined anterior arthroscopic and open posterior excision being considered the preferred method.
  • ➢ Radiation therapy has re-emerged as an additional treatment method for pigmented villonodular synovitis; however, the potential for serious toxicity makes it a questionable option, especially for such a benign condition.
  • ➢ Small molecule and monoclonal antibody targeted therapies are being investigated as novel treatment methods for pigmented villonodular synovitis, with promising results.

1Department of Orthopaedic Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania

2Cooper University Hospital, Camden, New Jersey

aE-mail address for S.R. Stephan:

bE-mail address for B. Shallop:

cE-mail address for R. Lackman:

dE-mail address for T.W.B. Kim:

eE-mail address for M.K. Mulcahey:

Copyright © 2016 by The Journal of Bone and Joint Surgery, Incorporated
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