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Osteochondral Allograft Transplantation for Knee Cartilage and Osteochondral Defects

A Review of Indications, Technique, Rehabilitation, and Outcomes

Cavendish, Parker A. BS1; Everhart, Joshua S. MD, MPH2; Peters, Nicholas J. MD2; Sommerfeldt, Mark F. MD3; Flanigan, David C. MD2

doi: 10.2106/JBJS.RVW.18.00123
Review Articles

  • » Osteochondral allograft (OCA) transplantation is a versatile treatment option for patients with cartilage and osteochondral defects. Indications for this procedure include young active patients with large focal defects, failure of previous cartilage repair, osteonecrosis, osteochondritis dissecans, and/or posttraumatic osteochondral defects.
  • » OCA transplantation is a uniquely useful treatment option for patients with large high-grade osteochondral defects and for athletes who have substantial incentives to return to sport as quickly as possible.
  • » Early reoperation after OCA transplantation is relatively common. Revision options for graft failure are limited. Thus, patients with contraindications such as a body mass index that is >35 kg/m2, uncorrectable malalignment of the knee joint, concomitant knee pathology, or a history of corticosteroid and/or tobacco use should be appropriately counseled.

1The Ohio State University College of Medicine, Columbus, Ohio

2The Ohio State University Division of Sports Medicine Cartilage Repair Center, Department of Orthopaedics, Columbus, Ohio

3Glen Sather Sports Medicine Clinic, University of Alberta, Edmonton, Alberta, Canada

E-mail address for D.C. Flanigan:

Investigation performed at The Ohio State University Wexner Medical Center, Columbus, Ohio

Disclosure: The authors indicated that no external funding was received for any aspect of this work. On the Disclosure of Potential Conflicts of Interest forms, which are provided with the online version of the article, one or more of the authors checked “yes” to indicate that the author had a relevant financial relationship in the biomedical arena outside the submitted work (

Copyright © 2019 by The Journal of Bone and Joint Surgery, Incorporated
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