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Cell-Based and Scaffold-Based Therapies for Joint Preservation in Early-Stage Osteonecrosis of the Femoral Head

A Review of Basic Research

Maruyama, Masahiro MD, PhD1; Lin, Tzuhua DVM, PhD1; Pan, Chi-Chun MS1,2; Moeinzadeh, Seyedsina PhD1; Takagi, Michiaki MD, PhD3; Yang, Yunzhi Peter PhD1; Goodman, Stuart B. MD, PhD1

doi: 10.2106/JBJS.RVW.18.00202
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  • » Numerous basic-science and translational studies of cell-based and scaffold-based therapies are currently being performed.
  • » The advantages and limitations of cell-based therapy for osteonecrosis of the femoral head, including bone marrow-derived mononuclear cells (BM-MNCs), mesenchymal stem cells (MSCs), and MSC-derived exosomes, are being examined preclinically.
  • » A range of ceramic-based, polymer-based, hydrogel-based, and composite scaffolds have been used for the treatment of osteonecrosis of the femoral head in order to physically or functionally support bone repair and remodeling.
  • » Modulation of the pro-inflammatory response at an appropriate time point has enhanced bone formation in experimental models. The therapeutic potential of these strategies in translational models of osteonecrosis of the femoral head has not been fully clarified.

1Departments of Orthopaedic Surgery (M.M., T.L., C.-C.P., S.M., Y.P.Y., and S.B.G.), Material Science and Engineering (Y.P.Y.), and Bioengineering (Y.P.Y. and S.B.G.), Stanford University School of Medicine, Stanford, California

2Department of Mechanical Engineering, Stanford University School of Engineering, Stanford, California

3Department of Orthopaedic Surgery, Yamagata University Faculty of Medicine, Yamagata, Japan

E-mail address for Y.P. Yang: ypyang@stanford.edu

E-mail address for S.B. Goodman: goodbone@stanford.edu

Investigation performed at the Stanford University School of Medicine, Stanford, California

Disclosure: This study was funded in part by National Institutes of Health (NIH) grants R01AR072613, R01AR057837, U01AR069395, R01AR073145, and R01AR063717 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJSREV/A508).

Copyright © 2019 by The Journal of Bone and Joint Surgery, Incorporated
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