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Pharmacogenomics Testing for Postoperative Pain Optimization Before Total Knee and Total Hip Arthroplasty

Awad, Mohamed E., MD1; Padela, Muhammad Talha, MD, MSc2,3,4,5,a; Sayeed, Zain, MD, MHA2,3,4,5; Abaab, Leila, MD3; El-Othmani, Mouhanad M., MD3; Saleh, Khaled J., MD, MSc, FRCS(C), MHCM, CPE5,b

doi: 10.2106/JBJS.RVW.17.00184
Review Articles
Disclosures

  • * Only 1 study has evaluated the effect of polymorphisms on postoperative pain following total knee arthroplasty and total hip arthroplasty.
  • * Opioids do not produce optimal analgesia for all patients; nevertheless, the personalization of opioid selection and dosing is not commonly practiced, most likely because of the paucity of evidence with regard to clinical outcomes and opioid pharmacogenomics in patients undergoing total joint arthroplasty.
  • * Further clinical trials are still required to establish the reliability and efficacy of the pharmacogenomics panel tests.

1Bone and Biomechanics Laboratories, Medical College of Georgia–Augusta University, Augusta, Georgia

2Resident Research Partnership, Detroit, Michigan

3Departments of Orthopaedic Surgery and Sports Medicine (M.T.P., Z.S., and M.M.E.) and Anesthesiology (L.A.), Detroit Medical Center, Detroit, Michigan

4Department of Orthopaedic Surgery, Rosalind Franklin University, Chicago Medical School, North Chicago, Illinois

5Michigan Musculoskeletal Institute, Madison Heights, Michigan

aE-mail address for M.T. Padela: tpadela@gmail.com

bE-mail address for K.J. Saleh: kjsaleh@gmail.com

Copyright © 2018 by The Journal of Bone and Joint Surgery, Incorporated
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