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A Comprehensive Review of Stem-Cell Therapy

Elbuluk, Ameer BA1,a; Einhorn, Thomas A. MD1,b; Iorio, Richard MD1,c

doi: 10.2106/JBJS.RVW.17.00002
Review Article

  • ➢ Regenerative orthopaedics has been used as a biological alternative to conventional therapy and surgical intervention for treating musculoskeletal conditions associated with limited therapeutic options.
  • ➢ Orthopaedic investigators have shown promising early clinical results by developing cell-based approaches to regenerate injured cartilage, tendon, ligaments, and bone.
  • ➢ Despite continued research, issues regarding harvesting, delivery of treatment, cost, indications, and optimal timing of intervention must be considered.
  • ➢ Multidisciplinary networks of investigators are essential to achieve the full clinical and therapeutic potential of mesenchymal stem cells in orthopaedics.
  • ➢ Although mesenchymal stem cells offer great promise for the treatment of degenerative diseases and orthopaedic conditions, there is still a dearth of properly conducted controlled clinical studies.

1Department of Orthopaedic Surgery, NYU Langone Medical Center, Hospital for Joint Diseases, New York, NY

aE-mail address for A. Elbuluk:

bE-mail address for T.A. Einhorn:

cE-mail address for R. Iorio:

Copyright © 2017 by The Journal of Bone and Joint Surgery, Incorporated
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