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Bisphosphonates in Orthopaedic Surgery

Morris, Carol D., MD, MS1; Einhorn, Thomas A., MD2

doi: 10.2106/JBJS.D.03032
Current Concepts Review

Bisphosphonates are the most clinically important class of antiresorptive agents available to treat diseases characterized by osteoclast-mediated bone resorption.

Currently, seven bisphosphonates have the approval of the United States Food and Drug Administration.

The most common adult diseases treated with bisphosphonates include osteoporosis, Paget disease, and metastatic bone disease.

The treatment of pediatric disorders such as osteogenesis imperfecta and fibrous dysplasia with bisphosphonates has gained momentum, and initial investigations have demonstrated an acceptable safety profile.

Currently, there is a lack of long-term follow-up data, which will be necessary for the development of responsible guidelines for therapy.

1 Orthopaedic Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Suite A-342, New York, NY 10021. E-mail address:

2 Department of Orthopaedic Surgery, Boston University Medical Center, 720 Harrison Avenue, Boston, MA 02116

Copyright © 2005 by The Journal of Bone and Joint Surgery, Incorporated
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