Ankle sprains are common injuries in healthy, active adults, especially those engaging in athletics or high-intensity training. Research assessing the effects and sequelae of sustained index ankle sprains demonstrates a high risk of subsequent injuries, leading to chronic ankle instability. Numerous studies have isolated risk factors and mitigation techniques, altering the progression of instability and decreased performance associated with ankle injuries. Enrollment in adequate early rehabilitation programs focused on the restoration of joint biomechanics and sensorineural control is essential in minimizing instability progression. The biomechanics, evaluation, special testing, and progressive spectrum of nonsurgical and surgically invasive treatment options are discussed.