Review ArticlesStem-Cell Therapy for the Treatment of Knee OsteoarthritisMeekin, Alexandra BSBA1,a; Sasek, Cody PhD, PA-C1 Author Information 1Physician Assistant Program, Creighton University, Omaha, NE aEmail address for corresponding author: [email protected] Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (https://links.lww.com/JBJSJOPA/A169). JBJS Journal of Orthopaedics for Physician Assistants: October-December 2021 - Volume 9 - Issue 4 - e21.00027 doi: 10.2106/JBJS.JOPA.21.00027 Buy Metrics Abstract Knee osteoarthritis (KOA) is a musculoskeletal disorder that causes progressive degeneration of the articular cartilage leading to pain and loss of function. Conservative treatment focuses on symptomatic relief with analgesics and nonsteroidal anti-inflammatory drugs. Mesenchymal stem cells (MSCs) have immunosuppressive and anti-inflammatory properties that aim to modify the disease process. Patients find improvement in function and pain after MSC therapy. MSC treatment stabilizes the cartilage, but there is no definitive regeneration. MSC therapy could be a treatment option for those wanting to stop or delay the disease process. This article reviews the current literature on the use of MSC therapy for patients with KOA. Copyright © 2021 by The Journal of Bone and Joint Surgery, Incorporated.