Review ArticlesAn Investigation in the Use of Propranolol as a Secondary Prevention of Post-traumatic Stress Disorder in Patients Sustaining Orthopaedic TraumaBhakta, Jai MS, PA-C1; Dewhirst, Brian MS, PA-C2; Villarreal, Peter MS, PA-C3; Kidd, Vasco Deon DHSc, MPH, MS, PA-C4Author Information 1Coastal Orthopedics, Torrance, California 2William C. Eves, M.D., Inc., Chula Vista, California 3Kaiser Permanente Fontana Medical Center, Department of Orthopaedics Fontana, California 4Orthopaedic Surgery, University of California Irvine (UCI Health), Orange, California Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJSJOPA/A106). JBJS Journal of Orthopaedics for Physician Assistants: July-September 2020 - Volume 8 - Issue 3 - p e20.00003 doi: 10.2106/JBJS.JOPA.20.00003 Metrics Abstract Objective: It has been well documented in various studies that individuals who sustain orthopaedic trauma are more likely to develop post-traumatic stress disorder (PTSD). The objective of our study is to assess the current literature regarding the use of propranolol for the treatment of PTSD and deliberate its use for patients who have sustained orthopaedic trauma. Conclusion: Although early studies show beneficial outcomes for patients treated with propranolol to prevent the progression of PTSD, these studies have limited sample sizes. We do not recommend the use of propranolol at this time; however, as more research emerges, it is likely that it may become a reliable option for treating patients in the future. We encourage orthopaedic providers to be cognizant of not only the physical injuries sustained in trauma but also the overall mental health of their patients. We recommend that patients who may be suffering from PTSD are referred to the appropriate psychiatric or mental health professional who can treat patients with cognitive behavioral therapy or with other pharmacological options. Further studies are also needed to investigate the effects of PTSD on outcomes in orthopaedic surgery. Copyright © 2020 by The Journal of Bone and Joint Surgery, Incorporated.