The 2 most common types of primary bone tumors in children and adolescents are osteosarcoma and Ewing sarcoma (ES). Common sites of presentation for ES include the long bones, pelvis, chest wall, and spine. Definitive diagnosis of ES is made via open or core needle biopsy. The standard treatment regimen of ES includes neoadjuvant chemotherapy, followed by local primary tumor control and then consolidative chemotherapy. In addition, ES is sensitive to radiation, and thus, radiotherapy is often implemented. Overall, the ES survival rates range from 70% to as low as 15% to 30% based on the stage.