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Relationship Between Nonsteroidal Anti-Inflammatory Drugs and Bone-Healing After Fracture or Orthopaedic Surgery

Bigler, Teresa, DHEd, PA-C1; Weidman-Evans, Emily, PharmD1; Flowers, Daniel, DPT1

JBJS Journal of Orthopaedics for Physician Assistants: April-June 2018 - Volume 6 - Issue 2 - p e14
doi: 10.2106/JBJS.JOPA.17.00036
Review Article

Inflammation is a complex physiologic response with various theoretical effects on the bone-healing process. Retrospective studies show conflicting results: some cases demonstrate that prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) leads to healing complications, while others negate this finding. Prospective studies have shown that NSAIDs offer quality pain control and possibly show no deleterious effects with early, short-term use. While some data are concerning regarding NSAID use during bone-healing, it is difficult to draw conclusions regarding predictive factors. Based on current studies, NSAIDs should be limited to short-term use.

1Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana

Copyright © 2018 by The Journal of Bone and Joint Surgery, Incorporated
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