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Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2

A Report of Two Cases

Wanderman, Nathan R., MD1,a; Drayer, Nicholas J., MD2,b; Tomov, Marko, MD1,c; Reifsnyder, Jeremy W., DO2,d; Carlson, Bayard, MD1,e; Robinson, William, MD1,f; Kang, Daniel G., MD2,g; Freedman, Brett, MD1,h

doi: 10.2106/JBJS.CC.18.00089
Case Reports

Case: We present 2 cases of postoperative seroma formation following posterior cervical fusion with the use of recombinant human bone morphogenetic protein-2 (rhBMP-2).

Conclusion: Although some who advocate for the off-label use of rhBMP-2 in patients undergoing posterior cervical spine fusion believe it to be safe, relatively little has been published regarding complication rates. We believe that rhBMP-2 carries a risk of seroma formation in patients who undergo posterior cervical fusion, which necessitates the use of a postoperative drain. Surgeons should have a low threshold for obtaining postoperative magnetic resonance imaging in a symptomatic patient.

1Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota

2Department of Orthopaedic Surgery, Madigan Army Medical Center, Tacoma, Washington

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Copyright © 2018 by The Journal of Bone and Joint Surgery, Incorporated
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