Granular Cell Tumor of the Hand: Unusual Malignancy of a Previous Benign Lesion: A Case Report : JBJS Case Connector

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Granular Cell Tumor of the Hand: Unusual Malignancy of a Previous Benign Lesion

A Case Report

Dauder Gallego, Cristina MD; Ruiz Zafra, Jorge MD; Stanescu, Ramona Ionela MD; Trujillo Coronado, María MD; Mena Rosón, María Araceli MD; Fahandezh-Saddi Díaz, Homid PhD

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JBJS Case Connector 11(3):e20.00503, July-September 2021. | DOI: 10.2106/JBJS.CC.20.00503

Abstract

Case: 

Malignant granular cell tumors are uncommon soft-tissue tumors. We describe a granular cell tumor that presented as a benign hand nodule diagnosed by biopsy and image. The patient refused local excision. After 15 years, the patient came back because of symptomatic growth, and a malignant granular cell tumor was diagnosed, with metastatic disease. Despite surgical disarticulation and adjuvant treatment, she died after 8 months. The pathological examination revealed the tumor had progressed to malignant behavior.

Conclusions: 

Our findings highlight the importance of a closer follow-up. Although unusual, we must be aware of the possibility of a change of behavior from benign to malignant granular cell tumor.

Copyright © 2021 by The Journal of Bone and Joint Surgery, Incorporated

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