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Langerhans Cell Histiocytosis of the Pediatric Thoracic Spine with Development of Neurological Compromise

A Case Report

Burkes, Jonathan C. MD, MBA1,2; Anderson, John T. MD2,3

doi: 10.2106/JBJS.CC.18.00159
Case Reports

Case: This report describes a 7-year-old girl with Langerhans cell histiocytosis (LCH) of the thoracic spine who developed neurological deterioration during nonsurgical management. She was treated with decompression and instrumented fusion followed by chemotherapy, recovered completely after surgery, and was doing well at 6-year follow-up.

Conclusions: The best treatment of LCH of the spine is not clear, but in the setting of neurologic compromise after failing conservative management, surgical decompression with adjuvant chemotherapy should be considered.

1Department of Orthopedic Surgery, Kansas University Medical Center, Kansas City, Kansas

2Department of Orthopedic Surgery, The Children's Mercy Hospital, Kansas City, Missouri

3University of Missouri—Kansas City School of Medicine, Kansas City, Missouri

E-mail address for J.C. Burkes:

Investigation performed at Children's Mercy Hospital, Kansas City, Missouri

Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (

Copyright © 2019 by The Journal of Bone and Joint Surgery, Incorporated
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