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Inflammatory Reactions to Xenogenic Nerve Wraps

A Report of Three Cases

Zeng, Wenjing MD1; Osterman, Meredith MD2; Stern, Peter J. MD3

doi: 10.2106/JBJS.CC.18.00302
Case Reports

Case: Recurrent carpal tunnel syndrome is a challenging problem. Nerve wraps have been introduced as a barrier to prevent scar traction neuritis for use during revision carpal tunnel surgery. We present 3 cases of inflammatory responses to bovine collagen and porcine subintestinal mucosal nerve wraps in patients undergoing revision carpal tunnel surgery. No patient had evidence of infection, and pathology revealed acute and chronic inflammation. All 3 patients responded favorably following wrap removal.

Conclusions: We recommend caution with the routine use of nerve wraps in the setting of revision carpal tunnel surgery.

1TriHealth Hand Surgery Specialists, Cincinnati, Ohio

2The Philadelphia Hand Center, King of Prussia, Pennsylvania

3Department of Orthopedics, University of Cincinnati College of Medicine, Cincinnati, Ohio

E-mail address for W. Zeng:

Investigation performed at Trihealth Hand Surgery Specialists, Cincinnati, Ohio and University of Cincinnati Department of Orthopedics, Cincinnati, Ohio

Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (

Copyright © 2019 by The Journal of Bone and Joint Surgery, Incorporated
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