This Month's Highlights Less Journal of the American Society of Nephrology. 34(1):i, January 2023. Favorite PDF Permissions Buy
Sweet-Talking the Distal Nephron Calcium-Sensing Receptor Subramanya, Arohan R. Subramanya, Arohan R. Less Journal of the American Society of Nephrology. 34(1):1-2, January 2023. Favorite PDF Permissions Buy Corresponding Article
Base (HCO3−/CO32−) Transport Properties of SLC4 Proteins: New Insights in Acid-Base Kidney Physiology Kurtz, Ira; Schwartz, George J. Kurtz, Ira; Schwartz, George J. Less Journal of the American Society of Nephrology. 34(1):8-13, January 2023. Abstract Abstract Favorite PDF Permissions Buy Corresponding Article
The Unintended Consequences of Changes to the Organ Allocation Policy Formica, Richard N. Jr.; Schold, Jesse D. Formica, Richard N. Jr.; Schold, Jesse D. Less Journal of the American Society of Nephrology. 34(1):14-16, January 2023. Favorite PDF Permissions Buy Corresponding Article
The New Kidney-Focused Companies: A Privatized Approach to Value-Based Care and Addressing Social Determinants of Health Lin, Eugene; Dave, Gaurav; Kshirsagar, Abhijit V. Lin, Eugene; Dave, Gaurav; Kshirsagar, Abhijit V. Less Journal of the American Society of Nephrology. 34(1):17-20, January 2023. Favorite PDF Permissions Free
Basic Requirements for Improving Home Dialysis Utilization: Universal Access to Specialty Nephrology Care and Comprehensive Pre-ESKD Education Shukla, A. M.; Cavanaugh, Kerri L.; Wadhwa, Anuradha; More Shukla, A. M.; Cavanaugh, Kerri L.; Wadhwa, Anuradha; Crowley, Susan T.; Fried, Linda Less Journal of the American Society of Nephrology. 34(1):21-25, January 2023. Favorite PDF Permissions Buy
Early Effect of the Circular Model of Kidney Allocation in the United States Puttarajappa, Chethan M.; Hariharan, Sundaram; Zhang, Xingyu; More Puttarajappa, Chethan M.; Hariharan, Sundaram; Zhang, Xingyu; Tevar, Amit; Mehta, Rajil; Gunabushanam, Vikraman; Sood, Puneet; Hoffman, William; Mohan, Sumit Less Journal of the American Society of Nephrology. 34(1):ASN.2022040471, January 2023. Abstract Abstract Favorite PDF Permissions Buy Infographic
Distinguishing among HCO3−, CO3=, and H+ as Substrates of Proteins That Appear To Be “Bicarbonate” Transporters Lee, Seong-Ki; Occhipinti, Rossana; Moss, Fraser J.; More Lee, Seong-Ki; Occhipinti, Rossana; Moss, Fraser J.; Parker, Mark D.; Grichtchenko, Irina I.; Boron, Walter F. Less Journal of the American Society of Nephrology. 34(1):40-54, January 2023. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Significance StatementSLC4 proteins play numerous important roles in the kidneys and elsewhere because they translocate what appears to be bicarbonate through cell membranes. Although previous studies supported three mechanisms with particular hypothesized substrate(s), HCO3−per se, CO3=, or H+, none could definitively discriminate among them. Now, novel three-dimensional mathematical simulations show that these mechanisms would cause markedly different cell-surface pH changes, normalized to translocated charge. Using electrophysiology to test these predictions for the electrogenic Na/HCO3 cotransporter NBCe1, the authors unambiguously rule out two mechanisms—those involving HCO3− and H+—and conclude that inward flux of CO3= is the only straightforward mechanism tenable. Thus, surface chemistry can differentiate three modes of acid-base transport previously thought to be indistinguishable. This mechanistic insight might have value for applications such as drug design. Buy SDC Corresponding Article Infographic
Hypoxia-Inducible Factor 2α Attenuates Renal Ischemia-Reperfusion Injury by Suppressing CD36-Mediated Lipid Accumulation in Dendritic Cells in a Mouse Model Qu, Junwen; Li, Dawei; Jin, Jingsi; More Qu, Junwen; Li, Dawei; Jin, Jingsi; Sun, Nan; Wu, Jiajin; Yang, Chao; Wu, Lingling; Zhuang, Shaoyong; Wu, Haoyu; Chen, Ruoyang; Ren, Yaofei; Zhong, Chen; Ying, Liang; Zhang, Yan; Yuan, Xiaodong; Zhang, Ming Less Journal of the American Society of Nephrology. 34(1):73-87, January 2023. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Significance StatementHypoxia is a hallmark of renal ischemia-reperfusion injury (IRI) and serves as an essential regulator of innate immune responses during this process, although the mechanisms of this regulation remain unclear. Here, we showed in a murine model that HIF-2α knockout in dendritic cells (DCs) exacerbated renal IRI through activation of natural killer T cells. Mechanistically, HIF-2α deficiency upregulated CD36 expression of DCs, leading to cellular lipid accumulation. Pharmacologic inhibition of CD36 in DCs resulted in renoprotection by reducing lipid content and suppressing natural killer T cell activation. Our study strongly suggests that targeting the HIF-2α/CD36 regulatory axis may be a strategy for alleviating renal IRI. Buy SDC Infographic
Kidney Organoids Generated Using an Allelic Series of NPHS2 Point Variants Reveal Distinct Intracellular Podocin Mistrafficking Dorison, Aude; Ghobrial, Irene; Graham, Alison; More Dorison, Aude; Ghobrial, Irene; Graham, Alison; Peiris, Thanushi; Forbes, Thomas A.; See, Michael; Das, Mithun; Saleem, Moin A.; Quinlan, Catherine; Lawlor, Kynan T.; Ramialison, Mirana; Howden, Sara E.; Little, Melissa H. Less Journal of the American Society of Nephrology. 34(1):88-109, January 2023. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: Significance StatementMissense variants of NPHS2 that cause mistrafficking of the encoded protein, PODOCIN, have been associated with steroid-resistant nephrotic syndrome. However, most studies have overexpressed such variants in 2D nonpodocyte cells. This study describes the generation and characterization of human kidney organoids representing an allelic series of homozygous NPHS2 missense variants. The strategy revealed a previously unappreciated reduction in variant PODOCIN protein, variant-specific subcellular localization, and specific effects on NEPHRIN association. All variants showed apoptosis in the absence of endoplasmic reticulum stress. Engineering endogenous NPHS2 variants to model in 3D human organoids provides a more accurate view of the pathobiology and a toolkit to screen compounds for reduction of variant protein degradation and mistrafficking. Go to Full Text of this Article Open SDC Corresponding Article Infographic
Testican-2 Is Associated with Reduced Risk of Incident ESKD Wen, Donghai; Zhou, Linda; Zheng, Zihe; More Wen, Donghai; Zhou, Linda; Zheng, Zihe; Surapaneni, Aditya; Ballantyne, Christie M.; Hoogeveen, Ron C.; Shlipak, Michael G.; Waikar, Sushrut S.; Vasan, Ramachandran S.; Kimmel, Paul L.; Dubin, Ruth F.; Deo, Rajat; Feldman, Harold I.; Ganz, Peter; Coresh, Josef; Grams, Morgan E.; Rhee, Eugene P.; on behalf of the CKD Biomarkers Consortium Less Journal of the American Society of Nephrology. 34(1):122-131, January 2023. Abstract Abstract Favorite PDF Permissions Buy Infographic
Genetic Variants of the COL4A3, COL4A4, and COL4A5 Genes Contribute to Thinned Glomerular Basement Membrane Lesions in Sporadic IgA Nephropathy Patients Yuan, Xiaohan; Su, Qing; Wang, Hui; More Yuan, Xiaohan; Su, Qing; Wang, Hui; Shi, Sufang; Liu, Lijun; Lv, Jicheng; Wang, Suxia; Zhu, Li; Zhang, Hong Less Journal of the American Society of Nephrology. 34(1):132-144, January 2023. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Significance StatementThinned glomerular basement membrane (tGBM) lesions, usually associated with COL4A3/COL4A4/COL4A5 gene variants, are not uncommon in sporadic IgA nephropathy (IgAN), but the underlying mechanism is unclear. Exome sequence analysis of 122 patients with sporadic IgAN with tGBM lesions (IgAN-tGBM) identified diagnostic COL4A3/COL4A4/COL4A5 gene variants in 38 patients (31.1%), with 37 different variants. Patients with IgAN-tGBM who did not have diagnostic variants showed more characteristics of IgAN, whereas those who did have diagnostic variants had higher proportions of GBM thickness <250 nm and milder glomerular injury. These findings suggest different mechanisms in patients with IgAN-tGBM with and without diagnostic variants in these collagen genes. The research indicated the importance of COL4A3/COL4A4/COL4A5 variant detection in patients with IgAN-tGBM. Buy SDC Infographic
Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial Hricik, Donald E.; Armstrong, Brian; Alhamad, Tarek; More Hricik, Donald E.; Armstrong, Brian; Alhamad, Tarek; Brennan, Daniel C.; Bromberg, Jonathan S.; Bunnapradist, Suphamai; Chandran, Sindhu; Fairchild, Robert. L.; Foley, David P.; Formica, Richard; Gibson, Ian W.; Kesler, Karen; Kim, S. Joseph; Mannon, Roslyn B.; Menon, Madhav C.; Newell, Kenneth A.; Nickerson, Peter; Odim, Jonah; Poggio, Emilio D.; Sung, Randall; Shapiro, Ron; Tinckam, Kathryn; Vincenti, Flavio; Heeger, Peter S. Less Journal of the American Society of Nephrology. 34(1):145-159, January 2023. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Significance StatementPeritransplant TNF blockade with infliximab should not be used in recipients of deceased-donor kidney transplants due to lack of efficacy and an increased incidence of BK virus infection, according to results of a randomized controlled clinical trial. Our results underscore the need for properly controlled and powered trials to avoid falsely accepting unproven therapeutics and reporting incorrect low adverse event rates derived from small, uncontrolled experiments. Buy SDC Infographic
A Crystal-Independent Role for Uric Acid in AKI Associated with Tumor Lysis Syndrome Ejaz, Abutaleb A.; Mohandas, Rajesh; Beaver, Thomas M.; More Ejaz, Abutaleb A.; Mohandas, Rajesh; Beaver, Thomas M.; Johnson, Richard J. Less Journal of the American Society of Nephrology. 34(1):175, January 2023. Favorite PDF Permissions Buy Corresponding Article
