Clinical Epidemiology

Genetic Variants Associated with Circulating Parathyroid Hormone

Robinson-Cohen, Cassianne^*,†; Lutsey, Pamela L.^‡; Kleber, Marcus E.^§; Nielson, Carrie M.^‖; Mitchell, Braxton D.^¶,**; Bis, Joshua C.^††; Eny, Karen M.^‡‡; Portas, Laura^§§; Eriksson, Joel^‖‖; Lorentzon, Mattias^‖‖; Koller, Daniel L.^¶¶; Milaneschi, Yuri^***; Teumer, Alexander^†††; Pilz, Stefan^{‡‡‡,§§§}; Nethander, Maria^‖‖‖; Selvin, Elizabeth^¶¶¶; Tang, Weihong^‡; Weng, Lu-Chen^‡; Wong, Hoi Suen^‡‡; Lai, Dongbing^¶¶; Peacock, Munro^****; Hannemann, Anke^††††; Völker, Uwe^‡‡‡‡; Homuth, Georg^‡‡‡‡; Nauk, Matthias^††††; Murgia, Federico^§§; Pattee, Jack W.^§§§§; Orwoll, Eric^‖; Zmuda, Joseph M.^‖‖‖‖; Riancho, Jose Antonio^¶¶¶¶; Wolf, Myles^{*****,†††††}; Williams, Frances^{‡‡‡‡‡}; Penninx, Brenda^***; Econs, Michael J.^¶¶,****; Ryan, Kathleen A.^¶; Ohlsson, Claes^‖‖; Paterson, Andrew D.^‡‡; Psaty, Bruce M.^{†††,§§§§§,‖‖‖‖‖}; Siscovick, David S.^{†,¶¶¶¶¶,******}; Rotter, Jerome I.^{††††††}; Pirastu, Mario^§§; Streeten, Elizabeth^¶; März, Winfried^{§,‡‡‡‡‡‡,§§§§§§}; Fox, Caroline^{‖‖‖‖‖‖}; Coresh, Josef^¶¶¶; Wallaschofski, Henri^††††; Pankow, James S.^‡; de Boer, Ian H.^*,†; Kestenbaum, Bryan^*,†

Author Information

^*Division of Nephrology, Department of Medicine, Kidney Research Institute,

^††Cardiovascular Health Research Unit, Department of Medicine, and

Departments of ^§§§§§Health Services and

^******Medicine, University of Washington, Seattle, Washington;

^†Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington;

Divisions of ^‡Epidemiology and Community Health and

^§§§§Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota;

^§Vth Department of Medicine, Mannheim Medical Faculty, Heidelberg University, Mannheim, Germany;

^‖Department of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, Oregon;

^¶Department of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland;

^**Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland;

^‡‡Program in Genetics & Genome Biology, Hospital for Sick Children, Toronto, Ontario, Canada;

^§§Institute of Population Genetics, National Research Council of Italy, Rome, Italy;

^‖‖Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, and

^‖‖‖Bioinformatics Core Facility, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;

Departments of ^¶¶Medical and Molecular Genetics and

^****Medicine, Indiana University, Indianapolis, Indiana;

^***Department of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Medical Center/GGZ inGeest, Amsterdam, The Netherlands;

Institutes for ^†††Community Medicine, Department Study of Health in Pomerania - Klinisch-Epidemiologische Forschung (SHIP-KEF), and

^††††Clinical Chemistry and Laboratory Medicine, and

^‡‡‡‡Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany;

^‡‡‡Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands;

^§§§Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, and

^§§§§§§Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria;

^¶¶¶Department of Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;

^‖‖‖‖Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania;

^¶¶¶¶Department of Medicine, University of Cantabria, and Hospital Universitario Marques de Valdecilla, Insituto de Investigacion Sanitaria, Santander, Spain;

^*****Division of Nephrology and Hypertension, Department of Medicine and

^{†††††}Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois;

^{‡‡‡‡‡}Department of Twin Research and Genetic Epidemiology, Division of Genetics & Molecular Medicine, King's College, London, United Kingdom;

^{‖‖‖‖‖}Group Health Research Institute, Group Health Cooperative, Seattle, Washington;

^¶¶¶¶¶The New York Academy of Medicine, New York, New York;

^{††††††}Department of Pediatrics and Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles, Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, California;

^{‡‡‡‡‡‡}Synlab Academy, Synlab Services GmbH, Mannheim, Germany; and

^{‖‖‖‖‖‖}Department of Genetics and Pharmacogenomics, Merck Research, Whitehouse Station, New Jersey

C.R.-C., P.L.L., M.E.K., and C.M.N. contributed equally to this work.

I.H.de B. and B.K. jointly directed this work.

Correspondence: Dr. Cassianne Robinson-Cohen, Kidney Research Institute, University of Washington, Division of Nephrology, Box 359606, Seattle, WA 98104-2499. Email: [email protected]

Journal of the American Society of Nephrology 28(5):p 1553-1565, May 2017. | DOI: 10.1681/ASN.2016010069