PDF OnlyGrowth hormone and the kidney a case presentation and review of the literature.O'Shea, M H; Layish, D T Author Information Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110. Journal of the American Society of Nephrology : JASN 3(2):p 157-161, August 1992. | DOI: 10.1681/ASN.V32157 Free Metrics Abstract Hypersomatotropism is accompanied by a significant increase in GFR and RPF. A case of a patient with acromegaly and supranormal renal function as measured by inulin and p-aminohippurate clearances is reported. The literature regarding the effects of growth hormone on renal function is reviewed, and the potential mechanisms of action and therapeutic implications of these effects are discussed. Copyright © 1992 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.