In 2021, the Journal of the Association of Nurses in AIDS Care released two special issues. The May/June special issue coincided with the June 1981 MMWR report introducing the world to what we now know as AIDS. This special issue includes a collection of nine state of the science papers related to issues of adherence, prevention, stigma, neurocognitive issues, and co-morbidities as well as manuscripts focusing on adolescents/young adults, cisgender women, sexual and gender minority peoples, and Black and Hispanic/Latinx individuals. The July/August issues focused on issues of racism, discrimination, and health inequities with three articles from this special issue being highlighted in this collection. Additionally, the 2021 JANAC collection also includes manuscripts examining viral suppression among U.S. adult, the social determinants of HIV treatment engagement among Black women living with HIV in the Southeastern U.S., Asian American women's recall of sexual health conversation with their mothers, nurse led pre-conception services for persons with HIV, the role of nurses and midwives in expanding and sustaining voluntary male medical circumcision in sub-Saharan Africa, MSM sex work in San Franciso, and a conceptual model exploring employment and occupational productivity among women living with HIV.