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Physical Activity, Depression, and Antiretroviral Therapy Adherence Among People Living With HIV

A Mediation Analysis

Bhochhibhoya, Amir PhD, MBA, CHES*; Qiao, Shan PhD; Mao, Yuchen PhD; Zhou, Yuejiao MD*; Shen, Zhiyong MD; Sui, Xuemei MD, MPH, PhD; Li, Xiaoming PhD

Journal of the Association of Nurses in AIDS Care: September-October 2019 - Volume 30 - Issue 5 - p 556–562
doi: 10.1097/JNC.0000000000000045
Research Article
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The aim of our study was to explore the relationships between physical activity, depression, and antiretroviral therapy (ART) adherence. Data were obtained from a randomized controlled trial of people living with HIV (N = 658) in China. Ordinal regression and logistic regression analyses were performed to examine associations between ART adherence, depression, and physical activity. A better ART adherence was associated with higher levels of physical activity (adjusted odds ratio [aOR] = 1.36, 95% confidence interval [CI] = 1.02–1.80) and lower levels of depression (aOR = 0.95, 95% CI = 0.92–0.99). Higher levels of physical activity were also associated with lower levels of depression (aOR = 0.50, 95% CI = 0.32–0.76). Sobel Z test indicated the mediating effect of depression between physical activity and ART adherence (Sobel Z = 1.96, p < .05). This study suggests the benefit of appropriate levels of physical activity to promote both psychological health and ART adherence in people living with HIV.

Amir Bhochhibhoya, PhD, MBA, CHES, is an Assistant Professor, School of Nursing, Lander University, Greenwood, South Carolina, USA. Shan Qiao, PhD, is an Assistant Professor, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA. Yuchen Mao, PhD, is a Research Associate, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA. Yuejiao Zhou, MD, is a Physician, Guangxi Centre for Disease Control and Prevention, Nanning, People's Republic of China. Zhiyong Shen, MD, is a Physician, Guangxi Centre for Disease Control and Prevention, Nanning, People's Republic of China. Xuemei Sui, MD, MPH, PhD, is an Assistant Professor and Graduate Director and Head of the Health Aspects of Physical Activity Division, University of South Carolina, Columbia, South Carolina, USA. Xiaoming Li, PhD, is a SmartState Endowed Chair for Clinical Translational Research, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.

Corresponding authors: Amir Bhochhibhoya, e-mail: abhochhibhoya@lander.edu and Yuejiao Zhou, e-mail: gxcdcj@163.com

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

© 2019 Association of Nurses in AIDS Care
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