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Relationship of HIV Status and Fatigue, Cardiorespiratory Fitness, Myokines, and Physical Activity

Webel, Allison R. RN, PhD*; Jenkins, Trevor MD; Longenecker, Christopher T. MD; Vest, Marianne RN; Davey, Christine Horvat RN, BSN, BSPS; Currie, Jackson BSN; Darrah, Rebecca PhD; Litman, Paul MS; Fernando de Oliveira, Vitor Hugo MS; Josephson, Richard A. MS, MD

Journal of the Association of Nurses in AIDS Care: July-August 2019 - Volume 30 - Issue 4 - p 392–404
doi: 10.1097/JNC.0000000000000022
Research Article
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People living with HIV (PLWH) experience high rates of fatigue, which can be improved with physical activity. We examined relationships between HIV infection, fatigue, cardiorespiratory fitness, physical activity, and myokines. Twenty PLWH and 20 HIV-uninfected adults completed a fatigue assessment, a maximal cardiometabolic exercise test, serum measures of myokines, and wore an accelerometer for 7 days. Measures were completed at baseline, 3 months, and 6 months. At baseline, PLWH had more fatigue (4.7 ± 2.6 vs. 2.8 ± 2.5, p = .01) and higher peak ventilatory efficiency (VE/VCO2; 33 ± 5.5 vs. 30.2 ± 2.5; p = .06). Half of PLWH engaged in at least one 10-minute bout of physical activity in the previous week, compared with control subjects (65%). Over time, HIV infection and fibroblast growth factor 21 were associated with fatigue (p < .05). People living with HIV have more fatigue and a higher ventilatory efficiency; expression of fibroblast growth factor 21 may underpin this relationship.

Allison R. Webel, RN, PhD, is an Assistant Professor, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, USA. Trevor Jenkins, MD, is an Assistant Professor, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Christopher T. Longenecker, MD, is an Assistant Professor, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Marianne Vest, RN, is a Senior Clinical Nurse, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA. Christine Horvat Davey, RN, BSN, BSPS, is a Research Assistant and Doctoral Student, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, USA. Jackson Currie, BSN, is a Research Assistant, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, USA. Rebecca Darrah, PhD, is an Associate Professor, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, USA. Paul Litman, MS, is a Research Assistant, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, USA. Vitor Hugo Fernando de Oliveira, MS, is a Doctoral Student, Londrina State, Paraná, Brazil. Richard A. Josephson, MS, MD, is a Professor, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Corresponding author: Allison R. Webel, e-mail: arw72@case.edu

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

© 2019 Association of Nurses in AIDS Care
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