FeatureApplication of the WHOQOL-HIV-BREF Questionnaire in HIV-Infected Thai Patients: Reliability and Validity of the InstrumentMeemon, Natthani PhD*; Paek, Seung Chun PhD; Yenchai, Daraphak MA; Wan, Thomas T.H. PhDAuthor Information *Correspondence to: E-mail: [email protected] Natthani Meemon, PhD, is a Lecturer, Faculty of Social Sciences and Humanities, Mahidol University, Salaya Campus, Nakhon Pathom, Thailand. Seung Chun Paek, PhD, is a Lecturer, Faculty of Social Sciences and Humanities, Mahidol University, Salaya Campus, Nakhon Pathom, Thailand. Daraphak Yenchai, MA, is a Graduate Research Assistant, Faculty of Social Sciences and Humanities, Mahidol University, Salaya Campus, Nakhon Pathom, Thailand. Thomas T.H. Wan, PhD, is a Professor, College of Health and Public Affairs, University of Central Florida, Orlando, Florida, USA. Journal of the Association of Nurses in AIDS Care: September 2016 - Volume 27 - Issue 5 - p 698-708 doi: 10.1016/j.jana.2016.04.007 Buy Metrics Abstract Given the prolonged survival of HIV-infected individuals as a result of widespread availability of treatment, health-related quality of life (HRQOL) becomes a relevant endpoint for assessing the impacts of HIV interventions. We examined the reliability and validity of the World Health Organization Quality of Life in HIV-infected Persons instrument (WHOQOL-HIV-BREF) using data from 329 HIV-infected Thai patients who received outpatient care at seven public hospitals. Our findings revealed acceptable reliability, construct validity, and convergent validity of the WHOQOL-HIV-BREF. No significant difference in HRQOL was found between groups with different CD4+ T cell counts. Conversely, the subgroup with a history of opportunistic infection appeared to have a higher HRQOL compared to those in the latency stage. Challenges to the interpretation of the questions related to culture are discussed. In conclusion, the WHOQOL-HIV-BREF can be added to the limited list of instruments for comprehensive outcome evaluation of HIV interventions in Thailand. © 2016Elsevier, Inc.