FeatureTwo-Year Prospective Cohort Study on Quality of Life Outcomes Among People Living With HIV After Initiation of Antiretroviral Therapy in Guangxi, ChinaMing, Zhongqiang, PhD; Prybylski, Dimitri, PhD, MPH; Cheng, Feng, PhD; Airawanwat, Rangsima, PhD; Zhu, Qiuying, MPH; Liu, Wei, MD; Huang, Shaobiao, MDAuthor Information Zhongqiang Ming, PhD, is a Member of the Adjunct Faculty, Research Center for Public Health, Tsinghua University and Program Manager of the FHI 360 China Office, Beijing, China. Dimitri Prybylski, PhD, MPH, is an Epidemiologist of the FHI 360 Asia Pacific Regional Office, Bangkok, Thailand. Feng Cheng, PhD, is a Professor, Research Center for Public Health, Tsinghua University and former Country Director of the FHI 360 China Office, Beijing, China. Rangsima Airawanwat, PhD, is an Associate Country Director of the FHI 360 China Office, Kunming City, Yunnan Province, China. Qiuying Zhu, MPH, is an Associate Professor, Guangxi Center for Disease Control and Prevention, Nanning, Guangxi Autonomous Region, China. Wei Liu, MD, is a Professor, Guangxi Center for Disease Control and Prevention, Nanning, Guangxi Autonomous Region, China. Shaobiao Huang, MD, is the Clinical Director, 4th Nanning Hospital ART Clinic, Nanning, Guangxi Autonomous Region, China. Journal of the Association of Nurses in AIDS Care: November 2014 - Volume 25 - Issue 6 - p 603-613 doi: 10.1016/j.jana.2014.04.003 Buy Metrics Abstract The long-term impact of antiretroviral therapy (ART) on quality of life (QOL) is not well understood in China. From 2007–2008, 332 treatment-naïve, HIV-infected adults from five hospitals in Guangxi were enrolled in a 2-year prospective cohort study. Information was collected at the time of ART initiation and during 6-, 12-, and 24-month follow-up visits. Significant improvements were observed across all QOL domains during the first 6 months on ART as measured using the WHOQOL-HIV BREF instrument. These were closely tracked by increases in CD4+ T cell counts, total lymphocyte counts, and the Karnofsky performance scores (p < .05). After 6 months, improvements were smaller and uneven across QOL domains; social relationships was the only domain to not significantly improve at 24 months compared to baseline. Poorer and socially isolated participants had lower QOL outcomes. Strengthening ART program interventions to increase social support for patients may increase QOL outcomes. © 2014Elsevier, Inc.