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A-104 Immune Targeting of the Latent Reservoir

Nixon, Douglas, F., MD, PhD

JAIDS Journal of Acquired Immune Deficiency Syndromes: April 2018 - Volume 77 - Issue - p 33
doi: 10.1097/01.qai.0000532485.54384.20
Abstracts: PDF Only

HIV is a human infectious exogenous retrovirus which is thought to have infected human populations from cross primate species transmissions. Within our genomes are remnants of past infectious retroviruses which have endogenized, called “endogenous retroviruses” (ERVs). We have previously shown that human ERVs (HERVs) can be transcribed in an HIV infected cell, but had not identified which sub-family or unique HERV was transcribed. Using a novel computational pipeline, Telescope, we have identified which HERVs are expressed in HIV infected cells.

We have received funding for a Martin Delaney Collaboratory grant called “Believe” in which we research towards HIV eradication based upon enhanced targeted cell therapy. As part of this program, we have investigated whether we can identify markers which uniquely identify the latent reservoir. New data will be presented on 2 putative markers, CD32a and IFITM1.

The George Washington University

Funding: The NIH Martin Delaney Collaboratory, “Believe,” NIAID UM1 award AI126617, co-funded by NIDA/NINDS/NIMH/NIAID; and grants NCI CA 206488; NIAID AI 76059.

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