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Efficacy and Immunologic Responses to Influenza Vaccine in HIV-1-Infected Patients

Yamanaka, Hikaru MD*†; Teruya, Katsuji MD*; Tanaka, Mari PhD*; Kikuchi, Yoshimi MD*; Takahashi, Takao MD; Kimura, Satoshi MD*; Oka, Shinichi MD*the HIV/Influenza Vaccine Study

JAIDS Journal of Acquired Immune Deficiency Syndromes: June 1st, 2005 - Volume 39 - Issue 2 - p 167-173
doi: 10.1097/01.qai.0000164151.50760.4c
Clinical Science

Influenza vaccine is recommended for HIV-1-infected patients. The present prospective study was conducted to evaluate the clinical efficacy and immunologic responses to the vaccine. From November 1 to December 27, 2002, 262 HIV-1-infected patients received a trivalent influenza subunit vaccine, whereas 66 did not. Influenza illness occurred in 16 vaccinated and 14 nonvaccinated patients (incidence = 6.1% [95% confidence interval (CI): 4%-10%] in vaccinated vs. 21.2% [CI: 13%-35%] in nonvaccinated persons, P < 0.001; relative risk = 0.29 [CI: 0.14-0.55]). Influenza vaccine provided clinically effective protection against influenza illness in HIV-1-infected patients. In baseline antibody-negative patients, anti-H1 and anti-H3 antibody responses to the vaccination were significant in those patients with a CD4 count >200 cells/μL compared with those with a CD4 count <200 cells/μL (P < 0.05). In contrast, in baseline antibody-positive patients, good antibody responses were observed irrespective of CD4 counts, like the healthy controls. Based on these results, annual vaccination is recommended. Specific CD4 responses correlated with HIV-1 viral load (VL), especially in patients treated with highly active antiretroviral therapy (HAART) compared with those without HAART (P < 0.01), although the clinical efficacy did not correlate with HIV-1 VL. HAART may enhance the immunologic efficacy of influenza vaccine.

From the *AIDS Clinical Center, International Medical Center of Japan, Tokyo, Japan; and †Department of Pediatrics, School of Medicine, Keio University, Tokyo, Japan.

Received for publication July 7, 2004; accepted March 16, 2005.

Supported in part by a grant for AIDS Research from the Ministry of Health, Labor, and Welfare of Japan (H15-AIDS-001) and by the Japanese Foundation for AIDS Prevention (H.Yamanaka).

Reprints: Shinichi Oka, AIDS Clinical Center, International Medical Center of Japan, 1-21-1, Toyama, Shinjuku-ku, Tokyo 162-8655, Japan (e-mail:

© 2005 Lippincott Williams & Wilkins, Inc.