Clinical Science

Brief Report: Frailty in Aging People Living With HIV: A Matched Controlled Study

Lellouche, Lionel MSCa,b; Gutierrez, Laure-Anne MSCa; Leclercq, Pascale MDc; Zaegel-Faucher, Olivia MDd; Bernard, Louis MD, PhDe; Vassallo, Matteo MDf; Barbuat, Claudine MDg; Ozguler, Anna MDh; Zins, Marie MD, PhDh; Nailler, Laurai; Reynes, Jacques MD, PhDj; Berr, Claudine MD, PhDa; Makinson, Alain MD, PhDj

Author Information

aInstitute for Neurosciences of Montpellier INM, University of Montpellier, Montpellier, France;

bEpidemiology of Animal and Zoonotic Diseases Unit, INRAE (Institut National de Recherche pour l'Agriculture, l'alimentation et l'Environnement), Marcy L'étoile, France;

cInfectious Disease Unit, University Hospital of Grenobles Alpes, and Fédération d'Infectiologie Multidisciplinaire de l'Arc Alpin, Université Grenoble Alpes, Grenoble, France;

dClinical Immuno-Hematology Department, Aix- Marseille University, Sainte-Marguerite University Hospital, Marseille, France;

eInfectious Diseases Unit, University Hospital Tours, Tours, France;

fDepartment of Internal Medicine, Cannes General Hospital, Cannes, France;

gInfectious Diseases Department, University Hospital, Nîmes, France;

hParis Descartes University Population-based Epidemiological Cohorts Unit, INSERM, Villejuif, France;

iDepartment of Clinical and Therapeutic Research on HIV and Hepatitis, ANRS (France Recherche Nord & Sud Sida-HIV Hépatites), Paris, France; and

jInfectious and Tropical Diseases Department, University Hospital Montpellier, Institut de Recherche et Développement, INSERMU1175, University of Montpellier, Montpellier, France.

Correspondence to: Alain Makinson, Département des Maladies Infectieuses, Hôpital La Colombière, 34295 Cedex 5, Montpellier, France (e-mail: [email protected]).

This study was sponsored by Inserm-ANRS (Institut national de la santé et de la recherche médicale—France Recherche Nord & Sud Sida-VIH Hépatites). The Constances Cohort benefits from a grant from ANR (ANR-11-INBS0002).

The authors have no conflicts of interest to disclose.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.jaids.com).

JAIDS Journal of Acquired Immune Deficiency Syndromes 88(3):p 305-309, November 1, 2021. | DOI: 10.1097/QAI.0000000000002759

Abstract

Background: 

We compared the prevalence of frailty among aging people living with HIV (PLHIV) with people without HIV from the ANS EP58 HAND 55–70 Study.

Methods: 

Cross-sectional multicentric study which consecutively included 200 PLHIV and 1000 people without HIV from the French national CONSTANCES cohort, matched on age, sex, and education level. PLHIV were aged 55–70 years, with a HIV viral load < 50 copies/mL and a lymphocyte T-CD4 level > 200 cells/µL for the last 24 and 12 months, respectively. We measured frailty (>2 items) and prefrailty (one or 2 items) using a proxy of the 5-item Fried score. Multivariate logistic regression was performed to assess the association between HIV and frailty/prefrailty, adjusting for demographic, social, behavioral, and comorbidity confounders.

Results: 

Outcome measures were available for 192 PLHIV and 822 people without HIV. The median age was 62 years, and 84.9% were men. Among PLHIV, the median CD4 cell count was 645.5 cells/µL. Prevalence of frailty/prefrailty was 5.73%/57.3% in PLHIV vs. 1.73%/52.2% in people without HIV, respectively. HIV was associated with prefrailty/frailty [odds ratio = 1.89; 95% confidence interval = 1.37 to 2.61), but after adjusting for social and behavioral factors and comorbidities, HIV was not significantly associated with prefrailty/frailty (odds ratio = 1.24; 95% confidence interval: = 0.84 to 1.81). In PLHIV only, frailty/prefrailty was associated with depressive symptomatology, kidney disease, and time since HIV infection.

Conclusions: 

Prevalence of frailty is increased in aging PLHIV with well-controlled HIV disease, but other factors than HIV are predominant, particularly depression and comorbidities.

Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Full Text Access for Subscribers:

Not a Subscriber?

Buy
Request Permissions

You can read the full text of this article if you:

Access through Ovid