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Opinions and Attitudes of Participants in a Randomized Controlled Trial Examining the Efficacy of SMS Reminders to Enhance Antiretroviral Adherence: A Cross-Sectional Survey

Reid, Michael J. A. MD*,†,‡; Dhar, Shumon I. MD§; Cary, Mark PhD; Liang, Patric BA; Thompson, James PhD#; Gabaitiri, Lesego PhD**; Steele, Katherine MD††; Mayisela, Susan RN*; Dickinson, Diana MBChB‡‡; Friedman, Harvey MD*,†,‡; Linkin, Darren R. MD, MSCE†,‡,‖; Steenhoff, Andrew P. MBBCh, DCH, FCPaed(SA)*,‡,§§,‖‖

JAIDS Journal of Acquired Immune Deficiency Syndromes: February 1st, 2014 - Volume 65 - Issue 2 - p e86–e88
doi: 10.1097/QAI.0b013e3182a9c72b
Letters to the Editor

*Botswana-UPenn Partnership, Gaborone, Botswana

Department of Medicine, University of Pennsylvania, Philadelphia, PA

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

§SUNY Upstate Medical University, New York, NY

Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA

Albert Einstein College of Medicine

#Wharton Social Entrepreneurship, Wharton Business School, University of Pennsylvania, Philadelphia, PA

**Department of Statistics, University of Botswana, Gaborone, Botswana

††Stony Brook University School of Medicine, New York, NY

‡‡Independence Surgery, Gaborone, Botswana

§§Department of Pediatrics, University of Pennsylvania, Philadelphia, PA

‖‖The Children's Hospital of Philadelphia, Philadelphia, PA

Supported by the Penn Center for AIDS Research, an National Institutes of Health–funded program (P30 AI 045008).

The authors have no conflicts of interest to disclose.

To the Editors:

Antiretroviral therapy (ART) has significantly reduced morbidity and mortality of people living with HIV/AIDS in sub-Saharan Africa.1 However, incomplete treatment adherence, leading to treatment failure, development of drug resistance, and HIV disease progression, remains a major concern.2,3 Although initial concerns about poor adherence leading to widespread drug resistance have not been realized, evidence does suggest that adherence among individuals in sub-Saharan Africa declines over time.4,5 Given the prohibitive costs of second-line therapy, successful, adherence support interventions may be cost saving.6

Increasing mobile phone ownership across southern Africa has raised the possibility that text messages using the short message service (SMS) can be used to improve ART adherence. Although there is an extensive data from high-income countries demonstrating that SMS technology is a feasible and cost-effective means of improving adherence to HIV management,6,7 research from Africa has not conclusively demonstrated that SMS improves adherence to ART.8,9 Despite the fact that SMS adherence interventions are being implemented widely by HIV programs across sub-Saharan Africa,10 it is also unclear if such interventions are acceptable to patients.

We sought to determine the acceptability of SMS interventions among participants in a randomized, controlled trial (RCT) evaluating the efficacy of SMS reminders to improve visit adherence in Gaborone, Botswana.11 Our objective was to establish whether using SMS reminders was acceptable to patients on ART.

We undertook a cross-sectional survey of the HIV-infected adults enrolled in an RCT evaluating the impact of SMS reminders on ART pharmacy collection and clinical outcomes. Participants were recruited from a single outpatient facility in Gaborone, Botswana. Those in the intervention arm of the trial received SMS reminders when medication refills were due, whereas the control group received no SMS reminders. At the end of the RCT, all participants were invited to participate in the survey to evaluate the acceptability of SMS reminders in HIV care.

The survey tool was based on similar questionnaires used in previous adherence research.12,13 All participants were invited to answer questions about (1) acceptability of SMS reminders as an adherence intervention, (2) perceived barriers to SMS reminders in HIV care, and (3) perspectives on the role of SMS interventions across the spectrum of HIV services. All interviews were conducted in English through telephone by the same investigator (S.I.D). The survey tool was piloted with study site nurses before being used with study participants.

The χ2 and Fisher exact tests were used to assess associations between responses to each component of the questionnaire in the control and intervention arms. Statistical analyses were performed using STATA software version 12 (STATA corporation, College Station, TX). A 2-sided P value of 0.05 was used to designate statistical significance. The Institutional Review Boards of the Botswana's Ministry of Health and the University of Pennsylvania approved this study.

Eighty-three patients (SMS, n = 42; control, n = 41) of the 128 originally randomized patients completed the full survey for a response rate of 65%. Of those who did not complete the survey, 39 could not be reached, 3 declined to answer, and 3 only partially completed the survey. Correcting for multiple tests, there was no significant difference in terms of age, gender, years of education, length of time on ART, or whether they had told someone about their HIV status between those who completed the survey and those who participated in the main RCT but did not participate in the survey.11 There were also no differences in these characteristics between the SMS and control groups.

Table 1 shows the survey responses by SMS group. Of those receiving the SMS reminders, 93% stated that SMS reminders were somewhat or very helpful, compared with 58% in the control group who felt that SMS reminders would be helpful (P < 0.001). Only 10% of those who received SMS reminders compared with 56% of those in the control group expressed concern that receiving SMS reminders might lead to inadvertent HIV status disclosure (P < 0.001).



For both groups, reminders to attend scheduled doctor's appointments were the primary information they would want from SMS messaging (46% of controls and 60% of SMS group). Only 20% of those who received SMS reminders and 5% of those in the control group stated that they would want to receive daily SMS pill reminders (P = 0.05). Controls felt that either morning (49%) or anytime (39%) would be the best time for receiving a message, whereas the SMS group preferred mornings (79%).

Of those who received SMS reminders, nearly all (95%) were satisfied with the appointment scheduling, and 90% would have liked to continue receiving SMS texts for future pill refills. Most (79%) would recommend this SMS service to others who have HIV. More than half (55%) felt that their opinion of the SMS service improved over the course of the study. The primary reasons reported for not collecting their pills were financial (36%), job obligations (17%), and not being able to get to the clinic (10%).

Our analysis is notable for 3 important findings that have significant implications for the implementation of SMS-based adherence interventions across southern Africa. First, the study demonstrates that SMS reminders—used to remind patients to attend clinic visits and pick up HIV medications—are acceptable to patients, with minimal intrusion into their daily lives. Notably, the results also demonstrate that those who had experienced SMS reminders were more favorably inclined to them than those who had not received SMS reminders and that in more than half of subjects, this favorable response improved during the duration of the study. Although data demonstrating the impact of SMS reminders on clinical outcomes, such as virologic suppression and CD4 recovery, are inconclusive,9,14 our research suggests that patient opposition to the intervention is unlikely to be a barrier to implementation. Given the high levels of enthusiasm among those in the intervention arm, our research also provides data to support using SMS-experienced peer educators to support any such scale up of this intervention in the same way in which such peer educators have been used to strengthen other areas of HIV service delivery.15,16

Second, our data supports the hypothesis that inadvertent HIV status disclosure is an important perceived obstacle to the use of SMS technology in southern Africa. A significant minority of participants who did not receive SMS reminders were concerned that SMS reminders might compromise their confidentiality. Despite high levels of phone ownership in Botswana, the practice of phone sharing is common.8 Consequently, it is not surprising that so many expressed concern about status disclosure. Several steps can be taken to mitigate the potential risk of disclosure (such as the use of general, non-HIV language). However, given that very few participants in the intervention arm expressed concern about accidental exposure, our data would also suggest that SMS reminders rarely led to HIV status disclosure in practice.

Third, the study demonstrates that patients did not want to receive SMS reminders for all areas of their HIV care. Although participants in both the groups supported SMS reminders to attend clinic appointments (60% in the intervention arm vs. 46% in the control arm), it is notable that only 20% of controls and 5% of cases expressed enthusiasm for daily SMS reminders to improve highly active ART adherence. This is consistent with the existing data showing that weekly SMS reminders improved pill adherence, whereas daily reminders did not 8,17. Habituation or the diminishing of a response to a frequently repeated stimulus may explain this finding. Daily messages may be perceived as intrusive. Furthermore, research is needed to distinguish the mechanisms as to why less frequent messages are most acceptable to participants.

There are several limitations to our study. Although we believe that the results have considerable bearing to other settings in southern Africa, we acknowledge that because participants were recruited from a single site, sampling bias may have influenced the results. Furthermore, the study sample size was small (n = 83), and we were unable to determine the impact of factors such as socioeconomic status and employment history on survey response. In addition, although the survey tool had been piloted before the initiation of the study, it had not been externally validated. Performing interviews in English may also have limited responses to questions for those participants for whom English was a second language. Furthermore, minor differences between survey content in intervention and control arms were inevitable as the groups had different experiences in the trial; although these differences were minimized, questions to each group were not identical. Although we recognize that many individuals in the main RCT did not participate in the acceptability survey, the demographic profile of these individuals was no different from those who took the survey, and thus, we believe that our results are representative of the individuals in the intervention study.

This research demonstrates that mobile phone technology is an acceptable tool for improving adherence to antiretroviral collection. Although HIV status disclosure is a potential obstacle to scale up of SMS adherence interventions as expressed by some participants, this was less of a concern in the intervention group. Consistent with the existing data from Africa, our analysis demonstrates that SMS reminders are perceived far more favorably for intermittent antiretroviral collection than for daily pill adherence.

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