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181 HTLV-1 Research after Three Decades: Insights into Cellular Transformation Mechanisms for ATL (Adult T-Cell Leukemia)

Jeang, Kuan-Teh

JAIDS Journal of Acquired Immune Deficiency Syndromes: April 2011 - Volume 56 - Issue - p 75
doi: 10.1097/01.qai.0000397363.76415.a6

National Institutes of Health, Bethesda, MD, USA

Human T-cell leukemia virus type 1 (HTLV-1) was first discovered in 1980. This retrovirus is the causative agent of an aggressive T-cell leukemia named Adult T-cell leukemia (ATL). To date the mechanism of how HTLV-1 transforms T-cells is not fully understood; however, it is accepted that the virus encode an oncogenic protein, Tax. I will update our current insights into the transforming routes employed by Tax to cause check point abrogation, DNA damage, and the creation of genomic instability. I will also discuss how the cancer stem cell hypothesis might apply to ATL.

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